Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Impact of Neutrophil-to-Lymphocyte Ratio on Stroke Severity and Clinical Outcome in Anterior Circulation Large Vessel Occlusion Stroke
Diagnostics · Aralık 2024
YÖKSİS Kayıtları
Impact of Neutrophil-to-Lymphocyte Ratio on Stroke Severity and Clinical Outcome in Anterior Circulation Large Vessel Occlusion Stroke
Diagnostics · 2024 SCI-Expanded
DOÇENT FETTAH EREN →
Makale Bilgileri
DergiDiagnostics
Yayın TarihiAralık 2024
Cilt / Sayfa14
Scopus ID2-s2.0-85213300936
Erişim🔓 Açık Erişim
Özet
Background: The prognostic value of the neutrophil–lymphocyte ratio (NLR) in ischemic stroke remains debated due to cohort variability and treatment heterogeneity across studies. This study evaluates the relationship between admission NLR, stroke severity and 90-day outcomes in patients with anterior circulation large vessel occlusion (LVO) undergoing early, successful revascularization. Methods: A retrospective multicenter study was conducted with 1082 patients treated with mechanical thrombectomy for acute ischemic stroke. The relationship between admission NLR, baseline National Institutes of Health Stroke Scale (NIHSS), 24 h NIHSS and 90-day modified Rankin Scale (mRS) outcomes was analyzed using logistic regression. Results: Admission NLR correlated weakly but significantly with both baseline (p = 0.018) and 24 h (p = 0.005) NIHSS scores, reflecting stroke severity. However, multivariate analysis showed that higher 24 h NIHSS scores (OR 0.831, p = 0.000) and prolonged puncture-to-recanalization times (OR 0.981, p = 0.000) were independent predictors of poor 90-day outcomes, whereas NLR was not (p = 0.557). Conclusions: Admission NLR is associated with stroke severity but does not independently predict clinical outcomes at 90 days in patients achieving early and successful revascularization. These findings underscore the critical role of inflammation in the acute phase of stroke but suggest that its prognostic value for long-term outcomes is limited in this context.
Yazarlar (37)
1
Zülfikar Memiş
ORCID: 0000-0002-5985-900X
2
Erdem Gürkaş
3
Atilla Özcan Özdemir
ORCID: 0000-0003-4028-1751
4
Bilgehan Atılgan Acar
ORCID: 0000-0002-2695-2152
5
Muhammed Nur Ögün
6
Emrah Aytaç
7
Çetin Kürşad Akpınar
8
Eşref Akıl
9
Murat Çabalar
10
Ayça Özkul
11
Ümit Görgülü
12
Hasan Bayındır
ORCID: 0000-0002-9260-2230
13
Zaur Mehdiyev
14
Şennur Delibaş Katı
15
Recep Baydemir
16
Ahmet Yabalak
ORCID: 0000-0002-3317-9567
17
Ayşenur Önalan
ORCID: 0000-0002-9939-2678
18
Türkan Acar
ORCID: 0000-0003-2001-914X
19
Özlem Aykaç
20
Zehra Uysal Kocabaş
21
Serhan Yıldırım
22
Hasan Doğan
23
Mehmet Semih Arı
24
Mustafa Çetiner
25
Ferhat Balgetir
26
Fettah Eren
27
Alper Eren
28
Nazım Kizildag
29
Utku Cenikli
30
Aysel Büşra Şişman Bayar
31
Ebru Temel
32
Alihan Abdullah Akbaş
ORCID: 0009-0005-6098-5096
33
Emine Saygın Uysal
34
Hamza Gültekin
35
Cebrail Durmaz
36
Sena Boncuk Ulaş
ORCID: 0000-0002-0076-9405
37
Talip Asil
Anahtar Kelimeler
inflammation
mechanical thrombectomy
neutrophil–lymphocyte ratio
prognostic biomarkers
stroke
Kurumlar
Abant Izzet Baysal University, Faculty of Medicine
Bolu Turkey
Ankara Bilkent City Hospital
Ankara Turkey
Ankara Etlik City Hospital
Ankara Turkey
Antalya Training and Research Hospital
Antalya Türkiye
Ataturk University, Faculty of Medicine
Erzurum Turkey
Basaksehir Cam and Sakura City Hospital
Istanbul Türkiye
Biruni Üniversitesi
Istanbul Turkey
Dicle University, Faculty of Medicine
Diyarbakir Turkey
Diyarbakir Devlet Hastanesi
Diyarbakir Turkey
Düzce Üniversitesi
Duzce Turkey
Erciyes University, Faculty of Medicine
Kayseri Turkey
Eskişehir Osmangazi Üniversitesi Tip Fakültesi
Eskisehir Turkey
Firat Üniversitesi Tip Fakültesi
Elazig Turkey
Independent Researcher
Sakarya Türkiye
Kocaeli City Hospital
Kocaeli Türkiye
Kütahya Sağlık Bilimleri Üniversitesi
Kutahya Turkey
Muğla Sıtkı Koçman Üniversitesi
Mugla Turkey
Sakarya Üniversitesi
Serdivan Turkey
Samsun University
Samsun Turkey
Selçuk Tip Fakültesi
Konya Turkey
University of Health Sciences
Istanbul Turkey