Scopus
🔓 Açık Erişim
Phytochemical profiling and biological evaluation of the residues from industrial hemp (Cannabis sativa L.) inflorescences trimming: Focus on water extract
Food Bioscience · Aralık 2024
Makale Bilgileri
DergiFood Bioscience
Yayın TarihiAralık 2024
Cilt / Sayfa62
Scopus ID2-s2.0-85207566185
Erişim🔓 Açık Erişim
Özet
The study focused on investigating the phytochemical composition and bio-pharmacological properties of a water extract obtained from industrial hemp by-products, after trimming female inflorescences of Cannabis sativa L., cultivar Kompolti. The extract was found to be rich in phenolic compounds, particularly gallic acid, catechin, coumaric acid, ferulic acid, and benzoic acid. It also contained significant amounts of cannabidiolic acid and cannabigerolic acid as the main terpenophenols. To assess the biological potential of the extract, various ecotoxicological assays were conducted. The extract did not show significant phytotoxic effects on seedling germination in the allelopathic assay. In the brine shrimp (Artemia salina) lethality test, the LC50 value was 1.726 mg/mL, and in the Daphnia magna test, the extract showed no cardiotoxicity effects at the same concentration; thus, confirming its biocompatibility with these eukaryotic organisms. Additionally, the extract did not induce cytotoxicity in the murine C2C12 cell line till to the concentration of 1000 μg/mL. In isolated mouse prostate specimens, the extract (10–1000 μg/mL) also prevented LPS-induced gene expression of pro-inflammatory cytokines, namely tumor necrosis factor (TNF)α, interleukin (IL)-6, and IL-1β. Furthermore, the extract exhibited inhibitory effects on the growth of pathogenic bacterial, fungal, and dermatophyte species commonly associated with prostatitis. These results suggest that the residual powder from female inflorescence trimming can be considered an innovative plant material from the industrial hemp supply chain that deserves to be valorised in terms of recycling and upcycling; thus, reducing the environmental impact of the by-products and also opening the way for innovative health-promoting agents.
Yazarlar (18)
1
Simonetta Cristina Di Simone
ORCID: 0000-0001-5041-3848
2
Maria Loreta Libero
ORCID: 0000-0002-8133-5691
3
Riccardo Pulcini
4
Nilufar Nilofar
5
Annalisa Chiavaroli
ORCID: 0000-0002-3399-967X
6
Fatma Tunali
ORCID: 0000-0003-1913-1353
7
Paola Angelini
ORCID: 0000-0002-6862-1079
8
Giancarlo Angeles Flores
ORCID: 0000-0001-6651-9794
9
Roberto Venanzoni
ORCID: 0000-0002-7768-0468
10
Gaia Cusumano
11
Gokhan Zengin
ORCID: 0000-0001-6548-7823
12
Luigi Brunetti
13
Lucia Recinella
14
Sheila Leone
15
Giustino Orlando
16
Luigi Menghini
ORCID: 0000-0002-7346-7395
17
Claudio Ferrante
18
Alessandra Acquaviva
Anahtar Kelimeler
Anti-inflammatory effects
Antimicrobial effects
Industrial hemp
Phenolic compounds
Terpenophenols
Water extract
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Perugia
Perugia Italy
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
2
Atıf
18
Yazar
6
Anahtar Kelime