Scopus
🔓 Açık Erişim
Enhancing diabetic rat peripheral nerve conduction velocity parameters through the potent effects of MitoTEMPO
Heliyon · Aralık 2024
Makale Bilgileri
DergiHeliyon
Yayın TarihiAralık 2024
Cilt / Sayfa10
Scopus ID2-s2.0-85211105229
Erişim🔓 Açık Erişim
Özet
The efficacy of MitoTEMPO, a mitochondria-targeted antioxidant, in altering nerve fiber conduction properties within the sciatic nerve of streptozotocin (STZ)-induced diabetic rats, a model for diabetic neuropathy characterized by myelinated fiber atrophy and nodal abnormalities. Utilizing the STZ-induced diabetic rat model, we assessed the impact of MitoTEMPO on nerve function through compound action potential (CAP) analysis and histological evaluation. Key indicators such as maximum depolarization (MD), CAP area, and conduction velocity distribution (CVD) were measured to gauge MitoTEMPO's neuroprotective effects, alongside physical parameters like weight and blood glucose levels. MitoTEMPO treatment significantly preserved CAP parameters (MD and CAP area), indicative of its protective role against diabetes-induced nerve dysfunction. Moreover, it mitigated the diabetes-induced disruption in CVD, suggesting a preservation of nerve fiber activity. Histological analyses corroborated these electrophysiological findings, showing reduced damage in MitoTEMPO-treated nerves, such as thinner perineurium and less myelin sheath degeneration. Our findings highlight MitoTEMPO's potential as a mitigative agent against diabetic neuropathy's detrimental effects on nerve structure and function. The study underscores the therapeutic promise of mitochondria-specific antioxidants in managing diabetic neuropathy, advocating for further clinical research to explore MitoTEMPO's applicability in novel treatment strategies for peripheral neuropathies.
Yazarlar (4)
1
Murat Cenk Celen
ORCID: 0000-0003-0727-0110
2
Seckin Tuncer
3
Ahmet Akkoca
ORCID: 0000-0001-8269-9385
4
Nizamettin Dalkilic
Anahtar Kelimeler
Diabetic neuropathy
MitoTEMPO
Nerve conduction velocity studies
Streptozotocin
Kurumlar
Ankara Medipol University
Ankara Turkey
Başkent Üniversitesi
Ankara Turkey
Eskişehir Osmangazi Üniversitesi Tip Fakültesi
Eskisehir Turkey
Selçuk Üniversitesi
Selçuklu Turkey