Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Therapeutic effect of Berberis vulgaris fruit extract on histopathological changes and oxidative stress markers of ovarian ischemia and reperfusion injury in rats
Journal of King Saud University - Science · Aralık 2024
YÖKSİS Kayıtları
Therapeutic effect of Berberis vulgaris fruit extract on histopathological changes and oxidative stress markers of ovarian ischemia and reperfusion injury in rats
Journal of King Saud University - Science · 2024 SCI
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiJournal of King Saud University - Science
Yayın TarihiAralık 2024
Cilt / Sayfa36
Scopus ID2-s2.0-85211454133
Erişim🔓 Açık Erişim
Özet
Aim: This study aimed to investigate the possible protective effect of berberine, the active compound of Berberis vulgaris plant extract, which has anti-inflammatory and antioxidant properties, in an ovarian ischemia–reperfusion model by utilizing molecular, biochemical, and histopathological methods. Methods: In this experimental study, 42 adolescent female Sprague Dawley rats (6 weeks old) were divided into 7 equal groups. Under anesthesia, ischemia was induced by ligating the bilateral adnexal tissues, and after 3 h of ischemia, reperfusion was achieved by removing the adnexal ligation. Berberis vulgaris extract was administered by oral gavage 1 h after ischemia for the ischemia groups and 1 h before reperfusion for the ischemia + reperfusion groups. After 3 h of reperfusion, the experiment was terminated. Results: The administration of Berberis vulgaris extract decreased the hemorrhagic areas, reduced the number of TUNEL-positive cells, and decreased CYC1 immunoreactivity levels in histopathological analysis compared to the groups subjected to ischemia or ischemia + reperfusion without the plant extract. CAT, SOD, and GSH increased due to Berberis vulgaris administration while MDA levels decreased. Berberis vulgaris also downregulated TNF-α levels compared to the ischemia and ischemia + reperfusion groups. Conclusion: Berberis vulgaris extract may have a protective effect against ovarian ischemia–reperfusion injury. Further molecular studies are needed to clarify this protective effect.
Yazarlar (15)
1
Serdar Yigit
ORCID: 0000-0001-5631-2335
2
Isa Yesilyurt
ORCID: 0000-0002-2164-4580
3
Soner Bitiktaş
4
Pinar Aksu Kilicle
ORCID: 0000-0002-3567-5775
5
Lale Duysak
ORCID: 0000-0001-7872-3880
6
Muhammed Yayla
ORCID: 0000-0002-0659-3084
7
Erdem Toktay
ORCID: 0000-0002-0715-2707
8
Nilnur Eyerci
ORCID: 0000-0002-6293-3338
9
Seyit Ali Bingol
ORCID: 0000-0001-6422-9582
10
Arzu Gezer
ORCID: 0000-0002-1658-2098
11
Fatma Necmiye Kaci
ORCID: 0000-0003-3745-8173
12
Ergin Taskin
ORCID: 0000-0002-1883-6055
13
Gül Esma Akdogan
ORCID: 0000-0001-7959-2130
14
Hasan Cilgin
ORCID: 0000-0002-7279-5995
15
Ali Alper Kahraman
ORCID: 0000-0003-2924-2655
Anahtar Kelimeler
Berberis vulgaris
Ischemia
Ovarian
Reperfusion
TNF-α
Kurumlar
Aǧrı İbrahim Çeçen Üniversitesi
Agri Turkey
Atatürk Üniversitesi
Erzurum Turkey
Erzurum Teknik Üniversitesi
Erzurum Turkey
Kafkas Üniversitesi
Kars Turkey