Scopus
YÖKSİS Eşleşti
A new lab-made screen-printed electrode system based on reduced graphene oxide-subphthalocyanine functionalized with ferrocene for electrochemical detection of acetaminophen
Microchemical Journal · Ocak 2025
YÖKSİS Kayıtları
A new lab-made screen-printed electrode system based on reduced graphene oxide-subphthalocyanine functionalized with ferrocene for electrochemical detection of acetaminophen
Microchemical Journal · 2025 SCI-Expanded
PROFESÖR MUSTAFA ÖZMEN →
A new lab-made screen-printed electrode system based on reduced graphene oxide-subphthalocyanine functionalized with ferrocene for electrochemical detection of acetaminophen
Microchemical Journal · 2025 SCI-Expanded
PROFESÖR SALİH ZEKİ BAŞ →
Makale Bilgileri
DergiMicrochemical Journal
Yayın TarihiOcak 2025
Cilt / Sayfa208
Scopus ID2-s2.0-85211697574
Özet
Acetaminophen (Ac) is a pharmaceutically active ingredient widely used in the treatment of pain and fever. However, an acute oral overdose of more than 12 g of Ac is considered a toxic dose and poses a high risk of liver damage. This study presents the development of a new laboratory-made screen-printed electrode modified with reduced graphene oxide (rGO)-subphthalocyanine-functionalized with ferrocene (SubPc-Fc) to detect Ac. Initially, subphthalocyanine (SubPc) was synthesized using a known method from the literature and was then functionalized with ferrocene (Fc). Subsequently, this functionalized compound was combined with rGO to form a composite structure (rGO–SubPc-Fc). A laboratory-made screen-printing electrode (LabSPE) was successfully created by using carbon and silver conductive inks applied to a polycarbonate substrate through the screen-printing process. Then, the surface of LabSPE was modified with rGO–SubPc-Fc composite and made ready for the electrochemical determination of Ac. The electrochemical results revealed that the rGO–SubPc-Fc composite exhibited a remarkable sensing behavior towards the oxidation of Ac with a working range from 0.05 μM to 200 μM, and a detection limit of 0.01 μM. The selectivity of the proposed sensor (rGO–SubPc-Fc/LabSPE) for Ac detection in the presence of possible interfering compounds such as uric acid, epinephrine, ascorbic acid, dopamine, and some ions was also examined. The practical suitability of rGO–SubPc-Fc/LabSPE in real sample analysis was tested on two different types of human drug samples and appreciable recovery results were obtained in the range of 102.02–103.94 %. In drug sample analysis, the proposed method was compared with the spectrophotometric method, and satisfactory results were achieved.
Yazarlar (11)
1
Haala Alahmad
2
Elif Yıldız Gül
ORCID: 0000-0001-7422-5665
3
Burcu Topaloğlu Aksoy
4
Fatih Biryan
5
Kenan Koran
ORCID: 0000-0002-2218-7211
6
Esra Tanrıverdi Eçik
7
Salih Zeki Bas
ORCID: 0000-0003-2822-8851
8
Keziban Atacan
9
Mustafa Ersöz
10
Mustafa Ozmen
ORCID: 0000-0001-5117-9168
11
Bünyemin Çoşut
Anahtar Kelimeler
Acetaminophen
Electrochemical sensor
Ferrocene
Lab-made SPE
Subphthalocyanine
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Firat Üniversitesi Tip Fakültesi
Elazig Turkey
Gebze Teknik Üniversitesi
Gebze Turkey
Sakarya University of Applied Sciences
Serdivan Turkey
Selçuk Üniversitesi
Selçuklu Turkey