Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Preparation of two new chiral metal-organic frameworks for lipase immobilization and their use as biocatalysis in the enantioselective hydrolysis of racemic naproxen methyl ester
International Journal of Biological Macromolecules · Aralık 2024
YÖKSİS Kayıtları
Preparation of two new chiral metal-organic frameworks for lipase immobilization and their use as biocatalysis in the enantioselective hydrolysis of racemic naproxen methyl ester
International Journal of Biological Macromolecules · 2024 SCI-Expanded
Prof. Dr. ELİF ÖZYILMAZ →
Preparation of two new chiral metal-organic frameworks for lipase immobilization and their use as biocatalysis in the enantioselective hydrolysis of racemic naproxen methyl ester
International Journal of Biological Macromolecules · 2024 SCI-Expanded
Prof. Dr. MUSTAFA YILMAZ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Immobilization and characterization of hemoglobin on modified sporopollenin surfaces
2012 ISSN: 0141-8130 SCI 2 atıf
Prof. Dr. MUSTAFA ÖZMEN →
Binding of actin to thioglycolic acid modified superparamagnetic nanoparticles for antibody conjugation
2015 ISSN: 01418130 SCI-Expanded
Prof. Dr. ESRA MALTAŞ ÇAĞIL →
Immobilization and characterization of hemoglobin on modified sporopollenin surfaces
2012 ISSN: 01418130 SCI-Expanded 1 atıf
Prof. Dr. ESRA MALTAŞ ÇAĞIL →
Magnetic nanoparticles serum proteins bioconjugates for binding of irinotecan
2015 ISSN: 01418130 SCI-Expanded
Prof. Dr. SALİH ZEKİ BAŞ →
Immobilization of Candida rugosa lipase on sporopollenin from Lycopodium clavatum
2009 ISSN: 0141-8130 SCI-Expanded
Prof. Dr. ELİF ÖZYILMAZ →
Magnetic nanoparticles serum proteins bioconjugates for binding of irinotecan
2015 ISSN: 01418130 SCI-Expanded
Prof. Dr. ESRA MALTAŞ ÇAĞIL →
Synthesis and characterization of novel nano chitosan Schiff base and use of lead II sensor
2012 ISSN: 01418130 SCI-Expanded 7 atıf
Prof. Dr. SEMAHAT KÜÇÜKKOLBAŞI →
Chitosan sporopollenin microcapsules Preparation characterisation and application in heavy metal removal
2015 ISSN: 01418130 SCI-Expanded
Prof. Dr. GÜLŞİN ARSLAN →
Immobilization and characterization of hemoglobin on modified sporopollenin surfaces
2012 ISSN: 01418130 SCI-Expanded 1 atıf
Prof. Dr. İLKAY HİLAL GÜBBÜK →
Magnetic nanoparticles serum proteins bioconjugates for binding of irinotecan
2015 ISSN: 01418130 SCI-Expanded 2 atıf
Prof. Dr. MUSTAFA ÖZMEN →
Characteristics of corneal lens chitin in dragonfly compound eyes
2016 ISSN: 01418130 SCI
Prof. Dr. GÜLŞİN ARSLAN →
Evaluation of antibacterial properties on polysulfone composite membranes using synthesized biogenic silver nanoparticles with Ulva compressa (L.) Kütz. and Cladophora glomerata (L.) Kütz. extracts
2018 ISSN: 01418130 SSCI
Prof. Dr. MUSTAFA ERSÖZ →
Supplementing capsaicin with chitosan-based films enhanced the anti-quorum sensing, antimicrobial, antioxidant, transparency, elasticity and hydrophobicity
2018 ISSN: 0141-8130 SCI
Prof. Dr. İDRİS SARGIN →
Characteristics of corneal lens chitin in dragonfly compound eyes
2016 ISSN: 01418130 SCI
Prof. Dr. İDRİS SARGIN →
Chitin extraction and characterization from Daphnia magna resting eggs
2013 ISSN: 0141-8130 SCI
Prof. Dr. İDRİS SARGIN →
Chitosan nanofiber production from Drosophila by electrospinning
2016 ISSN: 01418130 SCI
Prof. Dr. İDRİS SARGIN →
Chitosan/sporopollenin microcapsules: Preparation, characterisation and application in heavy metal removal
2015 ISSN: 01418130 SCI
Prof. Dr. İDRİS SARGIN →
Controlled release and anti-proliferative effect of imatinib mesylate loaded sporopollenin microcapsules extracted from pollens of Betula pendula
2017 ISSN: 01418130 SCI
Prof. Dr. İDRİS SARGIN →
Detailed adsorption mechanism of plasmid DNA by newly isolated cellulose from waste flower spikes of Thypa latifolia using quantum chemical calculations
2017 ISSN: 01418130 SCI
Prof. Dr. İDRİS SARGIN →
Effect of different animal fat and plant oil additives on physicochemical, mechanical, antimicrobial and antioxidant properties of chitosan films
2018 ISSN: 0141-8130 SCI
Prof. Dr. İDRİS SARGIN →
Makale Bilgileri
ISSN01418130
Yayın TarihiAralık 2024
Cilt / Sayfa282
Scopus ID2-s2.0-85207781243
Özet
Considering the selective pharmacological activity of chiral drugs, it is important to develop new chiral materials to synthesize them. In this work, two new chiral MOFs (UiO-66@Np and UiO-66@Ib) were prepared by the covalent attachment of the chiral compounds (S-naproxen and S-ibuprofen) to the amine-functionalized Zr-MOF (UiO-66-NH2). Then, Candida rugosa lipase (CRL) was immobilized on these chiral MOFs to fabricate two new biocomposites (UiO-66@Np@CRL and UiO-66@Ib@CRL) as effective biocatalysts, which enable significant enhancement in the catalytic activity and enantioselectivity of lipase. The FTIR, SEM, EDX, TGA, and PXRD analyses were carried out to confirm the formation of the biocomposites. The catalytic performances of the biocomposites (UiO-66@Np@CRL and UiO-66@Ib@CRL) were evaluated in the typical hydrolysis of p-nitro-phenyl palmitate (p-NPP) and the catalytic enantioselective hydrolysis of (R,S)-naproxen methyl ester. Under optimal conditions, UiO-66@Np@CRL showed a higher enantiomeric excess of the substrate (ees) value and a 98 % and 50 % conversion rate, respectively, than that of UiO-66@Ib@CRL. Besides, an excellent enantioselectivity (E) value of 458 was obtained in the presence of the biocomposite (UiO-66@Np@CRL). In addition, it was observed that the catalytic activity, conversion rate and ees value of this composite (UiO-66@Np@CRL) remained almost unchanged in reuse after 6 months. The results showed that in enantioselective reactions, the highest conversion and enantioselectivity could be achieved when the chiral compound bound to the MOF and the model compound used are the same.
Yazarlar (5)
1
Sebahat Ascioglu
2
Elif Ozyilmaz
3
Ayse Yildirim
4
Serkan Sayin
5
Mustafa Yilmaz
Anahtar Kelimeler
Chiral-MOF
Enantioselectivity
Lipase immobilization
S-naproxen
Kurumlar
Giresun Üniversitesi
Giresun Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
International Journal of Biological Macromolecules
Q1
SJR Skoru1,287
H-Index247
YayıncıElsevier B.V.
ÜlkeNetherlands
Biochemistry (Q1)
Biomaterials (Q1)
Food Science (Q1)
Structural Biology (Q1)
Molecular Biology (Q2)
Metrikler
11
Atıf
5
Yazar
4
Anahtar Kelime