Scopus
YÖKSİS Eşleşti
Antidiabetic Effect of Hydroalcoholic Extract of Myrtus communis L. Fruit in a Type 2 Diabetes Mouse Model
Acta Veterinaria Eurasia · Eylül 2024
YÖKSİS Kayıtları
Antidiabetic Effect of Hydroalcoholic Extract of Myrtus communis L. Fruit in a Type 2 Diabetes Mouse Model
Acta Veterinaria Eurasia · 2024 ESCI
PROFESÖR BÜNYAMİN TRAŞ →
Antidiabetic Effect of Hydroalcoholic Extract of Myrtus communis
L. Fruit in a Type 2 Diabetes Mouse Model
Acta Veterinaria Eurasia · 2024 zoological record
DOKTOR ÖĞRETİM ÜYESİ TUĞBA MELİKE PARLAK →
Antidiabetic Effect of Hydroalcoholic Extract of Myrtus communis L. Fruit in a Type 2 Diabetes Mouse Model
Acta Veterinaria Eurasia · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ BEYZA SUVARIKLI ALAN →
Antidiabetic Effect of Hydroalcoholic Extract of Myrtus communis L. Fruit in a Type 2 Diabetes Mouse Model
Acta Veterinaria Eurasia · 2024 ESCI
PROFESÖR BÜNYAMİN TRAŞ →
Antidiabetic Eect of Hydroalcoholic Extract of Myrtus communis L. Fruit in a Type 2 Diabetes Mouse Model
ACTA VETERINARIA EURASIA · 2024 Web of Science- Zoological Records • SCOPUS • DOAJ • EBSCO • TUBITAK ULAKBIM TR Index • China National Knowledge Infrastructure (CNKI) • Embase • Gale • AGRIS Nutrition Abstracts and Reviews Series B:Livestock Feeds • Nutrition and Food Database • Parasitology Database • Review of Medical and Veterinary Mycology • Veterinary Bulletin • ProQuest • CAS • CABI AgBiotechNet • CABI Animal Breeding Abtracts • CABI Animal Science Database • CABI CAB Abstracts • CABI Dairy Science Abstract • CABI Helmintological Abstracts • CABI Index Veterinarius • CABI VetMed Resource • CABI Poultry Abstracts • CABI Tropical Diseases Bulletin
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiActa Veterinaria Eurasia
Yayın TarihiEylül 2024
Cilt / Sayfa50 · 210-217
Scopus ID2-s2.0-85210385758
Özet
This study aimed to determine the effects of Myrtus communis L. fruit extract on the diabetes-related glycemic and lipid profile, some serum biochemical parameters, and mRNA expression of some endogenous substances in type 2 diabetes. A total of 54 healthy male Swiss albino mice were divided into 5 groups. Except for the mice in the healthy control group, the mice in the other group were fed high-fat diets, and streptozotocin (50 mg/kg) was administered. No medication was administered to the animals in the diabetes control group. Metformin (200 mg/kg), Myrtus communis L. fruit extract (2 g/kg), and metformin + Myrtus communis L. fruit extract were administered orally to D+ metformin, D + Myrtus communis L. fruit extract, and D + Myrtus communis L. fruit extract+ metformin groups for 14 days, respectively. In serum samples, glucose, triglyceride, cholesterol, aspartate aminotransferase, alanine aminotransferase, and blood urea nitrogen were measured with an autoanalyzer and hemoglobin A1C (Hb1Ac) was measured with an Hb1Ac analyzer. Adiponectin, insulin, leptin, and adenosine monophosphate-activated protein kinase levels were analyzed in an ELISA reader in serum samples. The mRNA expressions of glucose transporter-1 (GLUT-1), glucose transporter-4 (GLUT-4), peroxisome proliferator-activated receptor-α (PPAR-α), and peroxisome proliferator-activated receptor-γ (PPAR-γ) in the liver and striated muscles were determined with real-time polymerase chain reaction. Compared to the diabetic control group, Myrtus communis L. fruit extract significantly improved serum glucose, cholesterol, and triglyceride levels (p < .05) and significantly increased serum adiponectin, AMPK, and leptin levels (p < .05). The Myrtus communis L. fruit extract Myrtus communis significantly increased GLUT-1, PPAR-α, and PPAR-γ mRNA expressions in striated muscle tissue (p < .05) but did not cause any changes in the liver. In conclusion, it may be stated that the Myrtus communis L. fruit extract had a significant positive impact on both glucose and lipid metabolism. Further studies are needed to elucidate the mechanisms of action of Myrtus communis L. fruit extract and its application in human diabetes treatment.
Yazarlar (4)
1
T. M. Parlak
2
B. Traş
3
Kamil Üney
ORCID: 0000-0002-8674-4873
4
Beyza Suvarikli Alan
ORCID: 0000-0003-4698-9291
Anahtar Kelimeler
Glucose transporter
mouse
Myrtus communis
peroxisome proliferator-activated receptor
type 2 diabetes mellitus
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey