Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Effect of Body Size on Plasma and Tissue Pharmacokinetics of Danofloxacin in Rainbow Trout (Oncorhynchus mykiss)
Animals · Kasım 2024
YÖKSİS Kayıtları
Effect of Body Size on Plasma and Tissue Pharmacokinetics of Danofloxacin in Rainbow Trout (Oncorhynchus mykiss)
Animals · 2024 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiAnimals
Yayın TarihiKasım 2024
Cilt / Sayfa14
Scopus ID2-s2.0-85210246929
Erişim🔓 Açık Erişim
Özet
Changes in body size in fish can alter the pharmacokinetics of drugs, thereby affecting their therapeutic efficacy. Fish are among the animals that exhibit the greatest variability in body size during their life cycle. Despite being exposed to bacterial infections at all stages of life, the dosage regimens of antibacterial drugs have not been adjusted for age/body mass changes. The plasma and tissue pharmacokinetics of danofloxacin differed according to rainbow trout size. Pharmacokinetic/pharmacodynamic findings suggest that treatment efficacy is positively correlated with body size. However, in natural infections caused by susceptible bacteria, pharmacokinetic/pharmacodynamic studies in different fish sizes are needed to define optimal dosing regimens.
Yazarlar (7)
1
Kamil Üney
ORCID: 0000-0002-8674-4873
2
D. Durna Corum
3
Pedro Marin
ORCID: 0000-0003-4849-4452
4
Devran Coskun
ORCID: 0000-0003-1151-1861
5
Ertugrul Terzi
ORCID: 0000-0003-2811-6497
6
Elena Badillo
ORCID: 0000-0003-0888-4851
7
Orhan Corum
ORCID: 0000-0003-3168-2510
Anahtar Kelimeler
antibiotics
aquaculture
body size related pharmacokinetics
fluoroquinolones
HPLC
Kurumlar
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Siirt Üniversitesi
Siirt Turkey
Universidad de Murcia
Murcia Spain
University of Hatay Mustafa Kemal
Hatay Turkey