Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Efficacy of Resatorvid and Alpha-Lipoic Acid in Ameliorating Gentamicin-Induced Liver Injury: Insights from Rat Model Study
Pakistan Veterinary Journal · Ocak 2024
YÖKSİS Kayıtları
Efficacy of Resatorvid and Alpha-Lipoic Acid in Ameliorating Gentamicin-Induced Liver Injury: Insights from Rat Model Study
Pakistan Veterinary Journal · 2024 SCI-Expanded
DOÇENT DURMUŞ HATİPOĞLU →
Efficacy of Resatorvid and Alpha-Lipoic Acid in Ameliorating Gentamicin-Induced Liver Injury: Insights from Rat Model Study
Pakistan Veterinary Journal · 2024 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ BUSE KAVAKLI →
Efficacy of Resatorvid and Alpha-Lipoic Acid in Ameliorating Gentamicin-Induced Liver Injury: Insights from Rat Model Study
The Pakistan Veterinary Journal · 2024 SCI-Expanded
PROFESÖR BURAK DİK →
Efficacy of Resatorvid and Alpha-Lipoic Acid in Ameliorating Gentamicin-Induced Liver Injury: Insights from Rat Model Study
Pakistan Veterinary Journal · 2024 SCI-Expanded
DOÇENT MEHMET BURAK ATEŞ →
Makale Bilgileri
DergiPakistan Veterinary Journal
Yayın TarihiOcak 2024
Cilt / Sayfa44 · 931-937
Scopus ID2-s2.0-85207267870
Erişim🔓 Açık Erişim
Özet
The aim of our study was to investigate the potential effects of alpha-lipoic acid (ALA) and resatorvid (RES) on gentamicin-induced hepatotoxicity. Thirty-four rats were divided into the following groups: Healthy control (n=6), Gentamicin (GNT, 80 mg/kg, n=7), GNT + Sham (10% hydroalcoholic solution, n=7), GNT + RES (5 mg/kg, n=7), and GNT + ALA (100 mg/kg, n=7). In the GNT group, a statistically significant increase in ALT levels and a significant decrease in total protein (TP) and albumin (TA) levels were observed compared to the control group. On the other hand, a significant increase in NRF-2, NF-κB, NR4A2 and CAS-3 expression was detected in the GNT group as compared to the control group. Simultaneous administration of RES or ALA with GNT led to a significant decrease in ALT levels compared to the GNT group. In addition, these treatments caused a significant increase in TP and TA levels. RES administration caused a significant decrease in gene expression compared to the GNT group. On the other hand, simultaneous ALA treatment with GNT caused a significant decrease in NRF-2, CAS-3 and NF-κB expression and partially reduced NR4A2 expression. These findings draw attention to the potential of RES or ALA to alleviate gentamicin-induced hepatotoxicity and to their increased efficacy in the treatment of infections.
Yazarlar (5)
1
Durmus Hatipoglu
ORCID: 0000-0003-3790-7821
2
Mehmet Burak Ates
ORCID: 0000-0003-1297-426X
3
Aysegul Bulut
4
Buse Gezgic
5
Burak Dik
Anahtar Kelimeler
Alpha Lipoic Acid
Gentamicin
Hepatotoxicity
NRF2
Resatorvid
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
5
Yazar
5
Anahtar Kelime