Scopus
YÖKSİS Eşleşti
Effect of Salbutamol on the Disposition Kinetics of Levofloxacin in the Plasma and Lung of Rats
Current drug metabolism · Ocak 2024
YÖKSİS Kayıtları
Effect of Salbutamol on the Disposition Kinetics of Levofloxacin in the Plasma and Lung of Rats
Current Drug Metabolism · 2024 SCI-Expanded
PROFESÖR HALİS UĞUZ →
Makale Bilgileri
DergiCurrent drug metabolism
Yayın TarihiOcak 2024
Cilt / Sayfa25 · 425-430
Scopus ID2-s2.0-85210192996
Özet
BACKGROUND: Antibiotics and bronchodilator drugs can be used together in respiratory distress caused by bacterial infections. Levofloxacin (LVX) and Salbutamol (SLB) can be used simultaneously in respiratory distress. However, there have been no investigations on how the concurrent use of SLB can affect the pharmacokinetics of LVX in rats. OBJECTIVE: The purpose of this study was to investigate the influence of SLB on the plasma and lung pharmacokinetics of LVX in rats. METHODS: A total of 132 rats were randomly assigned to two groups: LVX (n=66) and LVX+SLB (n=66). LVX (intraperitoneal) and SLB (oral) were administered to rats at doses of 50 and 3 mg/kg, respectively. The concentrations of LVX in the plasma and lungs were determined through the utilization of high-performance liquid chromatography along with UV. Pharmacokinetic parameters were assessed by non-compartmental analysis. RESULTS: The area under the curve from 0 to 16 h (AUC0-16), terminal elimination half-life, volume of distribution, total body clearance, and peak concentration of LVX in the plasma were 42.57 h*μg/mL, 2.32 h, 3.91 L/kg, 1.17 L/h/kg, and 23.96 μg/mL, respectively. There were no alterations observed in the plasma and lung pharmacokinetic parameters of LVX when co-administered with SLB. The AUC0-16 lung/AUC0-16 plasma ratios of LVX were 1.60 and 1.39 after administration alone and co-administration with SLB, respectively. CONCLUSION: The concentration of LVX in lung tissue was higher than that in plasma. SLB administration to rats did not affect the plasma and lung pharmacokinetics and lung penetration ratio of LVX. There is a need to reveal the change in the pharmacokinetics of LVX after multiple administration of both drugs and after administration of SLB by different routes.
Yazarlar (3)
1
Murat Ali Cicekler
ORCID: 0000-0001-8637-828X
2
H. Oǧuz
3
Orhan Corum
ORCID: 0000-0003-3168-2510
Anahtar Kelimeler
HPLC
levofloxacin
liquid chromatography.
optical L-isomer
pharmacokinetics
salbutamol
Kurumlar
Kadinhani Refik Saime Koyuncu Public Hospital
Konya Turkey
Mustafa Kemal Üniversitesi
Antakya Turkey
Selçuk Üniversitesi
Selçuklu Turkey