Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Synthesis, characterization, antimicrobial, antioxidant, and anti-cancer activity of new hybrid structures based on benzimidazole and thiadiazole
Brazilian Journal of Pharmaceutical Sciences · Ocak 2025
YÖKSİS Kayıtları
Synthesis, characterization, antimicrobial, antioxidant, and anti-cancer activity of new hybrid structures based on benzimidazole and thiadiazole
Brazilian Journal of Pharmaceutical Sciences · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ AYŞEN IŞIK →
Makale Bilgileri
DergiBrazilian Journal of Pharmaceutical Sciences
Yayın TarihiOcak 2025
Cilt / Sayfa61
Scopus ID2-s2.0-85216653445
Erişim🔓 Açık Erişim
Özet
Hybrid structures containing multiple pharmacophore units with known activity have attracted attention due to their promising outcomes. In this study, several new hybrid structures containing benzimidazole and thiadiazole units were synthesized. The newly synthesized compounds were structurally analyzed using1 H-NMR,13 C-NMR, HRMS, and elemental analysis. The antimicrobial, in vitro anti-cancer, and antioxidant activities of all compounds were investigated. In vitro antimicrobial activities of the compounds were determined against Gram-positive (S. aureus ATCC 29213, E. faecalis ATCC 29212), Gram-negative (E. coli ATCC 25922, P. aeruginosa ATCC 27853) bacteria and fungi (C. albicans ATCC 10231) by using broth microdilution method. The compound 5g bearing 4-methoxyphenyl derivative showed the best activity with 32 μg/mL against S. aureus ATCC 29213 and P. aeruginosa ATCC 27853. The MTT test was used to determine the cytotoxicity of the produced compounds on the MCF-7 (human breast cancer) and L-929 (fibroblast) cell lines. FRAP method was used to determine the antioxidant properties of synthesized compounds. The Ferric Reducing Antioxidant Power of the compounds 5a, 5b, and 5c showed more antioxidant properties than vitamin E. The compound 5g stands out in the series in that it is not toxic on the healthy cell line and has promising antimicrobial activity.
Yazarlar (7)
1
Hayrani Eren Bostancı
2
Ulviye Acar Çevik
ORCID: 0000-0003-1879-1034
3
Ayşen Işık
4
Zahra Maryam
5
Ufuk İnce
6
Yusuf Özkay
7
Zafer Asım Kaplancıklı
Anahtar Kelimeler
Anti-cancer
Antimicrobial
Antioxidant
Benzimidazole
Thiadiazole
Kurumlar
Anadolu Üniversitesi
Eskisehir Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Erciyes Üniversitesi
Kayseri Turkey
Selçuk Üniversitesi
Selçuklu Turkey