Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Development of phytase targeted PLGA nanoparticles loaded with albendazole sulfoxide and praziquantel and evaluation of efficacy on the hydatid cysts
Journal of Drug Delivery Science and Technology · Mart 2025
YÖKSİS Kayıtları
Development of phytase targeted PLGA nanoparticles loaded with albendazole sulfoxide and praziquantel and evaluation of efficacy on the hydatid cysts
Journal of Drug Delivery Science and Technology · 2025 SCI-Expanded
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Development and in vitro evaluation of temozolomide-loaded PLGA nanoparticles in a thermoreversible hydrogel system for local administration in glioblastoma multiforme
2020 ISSN: 1773-2247 SCI-Expanded
Dr. Öğr. Üyesi SEMA ARISOY →
In-vivo evaluation of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers and mesenchymal stem cells in diabetic wound healing
2021 ISSN: 1773-2247 SSCI Q2
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Formulation and characterization of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers for treatment of diabetic wounds
2017 ISSN: 1773-2247 SSCI
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Formulation and in vitro evaluation of topical nanoemulsion and nanoemulsion-based gels containing daidzein
2019 ISSN: 1773-2247 SSCI
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Development and characterization of polymeric nanoparticles containing ondansetron hydrochloride as a hydrophilic drug
2022 ISSN: 1773-2247 SCI-Expanded Q2
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
2022 ISSN: 1773-2247 SCI-Expanded
Arş. Gör. TAMER TEKİN →
Preparation, characterization and evaluation of liposomal-freeze dried anthocyanin-enriched Vaccinium arctostaphylos L. fruit extract incorporated into fast dissolving oral films
2022 ISSN: 1773-2247 SCI-Expanded Q1
Prof. Dr. YÜKSEL KAN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
2022 ISSN: 1773-2247 SCI-Expanded
Prof. Dr. ZELİHA ESİN ÇELİK →
Preparation and evaluation of fast-dissolving albendazole sulfoxide and praziquantel-loaded polyvinylpyrrolidone nanofiber films by electrospinning
2024 ISSN: 1773-2247 SCI Q1
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Multifunctional hernia repair biopatch: Development, characterization, in vitro and in vivo evaluation
2024 ISSN: 1773-2247 SCI-Expanded Q1
Prof. Dr. MEHMET TUZCU →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded
Dr. Öğr. Üyesi ŞEYMA TETİK RAMA →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Arş. Gör. KÜBRA YILMAZ →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Dr. Öğr. Üyesi HARUN YONAR →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Öğr. Gör. FATİH ÖZCAN →
Development of phytase targeted PLGA nanoparticles loaded with albendazole sulfoxide and praziquantel and evaluation of efficacy on the hydatid cysts
2025 ISSN: 1773-2247 SCI-Expanded Q1
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Makale Bilgileri
ISSN17732247
Yayın TarihiMart 2025
Cilt / Sayfa105
Scopus ID2-s2.0-85216673689
Özet
Cystic echinococcosis is the metacestode stage of Echinococcus granulosus and is a worldwide public health problem. Today, various difficulties in the treatment of cystic echinococcosis limit the treatment of cystic echinococcosis. In this study, the in vitro activity of PLGA nanoparticles loaded with albendazole sulfoxide and praziquantel and targeted with phytase enzyme on Echinococcus granulosus micro-hydatid cysts was evaluated as a new formulation. For this purpose, first conjugation of PLGA polymer and phytase enzyme was performed, then albendazole sulfoxide and praziquantel loaded nanoparticles were prepared using PLGA-phytase polymer and characterization studies were performed. Permeability and cytotoxicity tests were carried out with cell culture studies of the formulations for which characterization studies were performed and it was found that the formulations did not show any cytotoxic effect. In order to evaluate the formulations, micro-hydatid cysts were developed in vitro with Echinococcus granulosus protoscoleces collected from slaughterhouse animals and the formulations were applied. In vitro hydatid cyst viability studies, approximately 50 % of cysts died on day 4 in the group applied with the combination of 10 μg/mL free albendazole sulfoxide and 50 μg/mL free praziquantel, while 100 % of cysts died in the group applied with the new formulation containing the same amount of drug. In addition, ex vivo studies on the laminar layer of hydatid cysts obtained from sheep liver showed that the new formulation binds to the laminar layer and increases the permeability of albendazole sulfoxide and praziquantel across the laminar layer by approximately 2-fold.
Yazarlar (6)
1
Yakup Gultekin
2
Çağla Korkmaz
3
Naile Öztürk
4
Ayhan Filazi
ORCID: 0000-0002-2800-6215
5
Ahmet Deniz
6
İmran Vural
Anahtar Kelimeler
Albendazole sulfoxide
Hydatid cyst
Phytase enzyme
Praziquantel
Targeted nanoparticles
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Inönü Üniversitesi
Malatya Turkey
Kafkas Üniversitesi
Kars Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Veterinary Control Central Research Institute
Ankara Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Drug Delivery Science and Technology
Q2
SJR Skoru0,780
H-Index102
YayıncıEditions de Sante
ÜlkeFrance
Pharmaceutical Science (Q2)
Metrikler
1
Atıf
6
Yazar
5
Anahtar Kelime