Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Tobacco induces abnormal metabolism of tryptophan via the kynurenine pathway
Turkish Journal of Biochemistry · Ocak 2025
YÖKSİS Kayıtları
Tobacco induces abnormal metabolism of tryptophan via the kynurenine pathway
Turkish Journal of Biochemistry · 2025 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Makale Bilgileri
DergiTurkish Journal of Biochemistry
Yayın TarihiOcak 2025
Scopus ID2-s2.0-85214849451
Erişim🔓 Açık Erişim
Özet
Objectives: This study aims to investigate the effect of smoking on the metabolism of kynurenine and thus contribute to the elucidation of the potential mechanism of cigarette smoking. Methods: The study included 82 smokers and 63 nonsmokers who applied to the Family Medicine Polyclinic for routine check-ups. Sociodemographic data, routine laboratory results, Framingham risk scores (FRS), and Fagerström Nicotine Dependence Test (FTND) were recorded. Serum tryptophan, kynurenine, kynurenic acid, 3-hydroxyanthranilic acid, 3-hydroxykynurenine, and quinolinic acid concentrations were measured with tandem mass spectrometry. Results: Serum tryptophan levels (p=0.040) were statistically significantly lower in smokers, and the kynurenine/ tryptophan ratio and serum kynurenine, kynurenic acid, quinolinic acid, 3-hydroxyanthranilic acid levels were higher (p<0.001). The correlation analysis in the smoker group showed a positive correlation between serum kynurenic acid levels and FTDN. The serum kynurenine levels were positively correlated with the levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, and FRS. There was a positive correlation between serum quinolinic acid levels and participants’ systolic and diastolic blood pressures. Conclusions: Our findings showed that tryptophan metabolism via the kynurenine pathway was induced in smokers.
Yazarlar (6)
1
Mustafa Onmaz
2
Duygu Eryavuz Onmaz
ORCID: 0000-0001-8564-1824
3
Nur Demirbaş
ORCID: 0000-0002-4038-9386
4
Ruhuşen Kutlu
5
Ali Ünlü
ORCID: 0000-0002-9991-3939
6
Ahmet Emre Hatir
ORCID: 0000-0001-8094-3444
Anahtar Kelimeler
kynurenine
oxidative stress
smoking
tobacco
tryptophan
Kurumlar
Bandırma Onyedi Eylül University
Bandirma Turkey
Fetih Family Health Center
Konya Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey
Uluırmak Family Health Center
Konya Turkey