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A smart probe for detection of sugar markers for applications in gastrointestinal barrier dysfunction

Biosensors and Bioelectronics · Mart 2025

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YÖKSİS Kayıtları
A smart probe for detection of sugar markers for applications in gastrointestinal barrier dysfunction
Biosensors and Bioelectronics · 2025 SCI-Expanded
Dr. Öğr. Üyesi MERVE GÖKŞİN KARAASLAN TUNÇ →
A SMART PROBE FOR DETECTION OF SUGAR MARKERS FOR APPLICATIONS IN GASTROINTESTINAL BARRIER DYSFUNCTION
Biosensors and Bioelectronics · 2024 SCI
Dr. Öğr. Üyesi MERVE GÖKŞİN KARAASLAN TUNÇ →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 7 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
1 10 Phenanthroline derivatives as mediators for glucose oxidase
2010 ISSN: 09565663 SSCI
Prof. Dr. ZAFER YAZICIGİL →
Direct electron transfer from glucose oxidase immobilized on polyphenanthroline modified glassy carbon electrode
2011 ISSN: 09565663 SSCI
Prof. Dr. ZAFER YAZICIGİL →
1 10 Phenanthroline derivatives as mediators for glucose oxidase
2010 ISSN: 09565663 SCI-Expanded
Prof. Dr. YASEMİN ÖZTEKİN →
Direct electron transfer from glucose oxidase immobilized on polyphenanthroline modified glassy carbon electrode
2011 ISSN: 09565663 SCI-Expanded
Prof. Dr. YASEMİN ÖZTEKİN →
An electrochemical biosensor based on human serum albumin graphene oxide 3 aminopropyltriethoxysilane modified ITO electrode for the enantioselective discrimination of d and l tryptophan
2013 ISSN: 09565663 SCI-Expanded
Prof. Dr. İMREN HATAY PATIR →
Graphene-based hybrid for enantioselective sensing applications
2017 ISSN: 09565663 SCI-Expanded
Prof. Dr. MUSTAFA ERSÖZ →
A smart probe for detection of sugar markers for applications in gastrointestinal barrier dysfunction
2025 ISSN: 0956-5663 SCI-Expanded Q1
Dr. Öğr. Üyesi MERVE GÖKŞİN KARAASLAN TUNÇ →

Makale Bilgileri

Dergi Biosensors and Bioelectronics
ISSN09565663
Yayın TarihiMart 2025
Cilt / Sayfa272
DOI10.1016/j.bios.2024.117040
Scopus ID2-s2.0-85213569660
Özet Gastrointestinal (GI) barrier dysfunction is an early pathogenic event in many complex diseases. Despite the routine applications of invasive tests, saccharide molecules are used noninvasively for assessing GI tract mucosal barrier function. However, currently available methods for quantification of saccharides molecules are costly and laborious. Simplified, reliable, and high-throughput methods are desired so that GI permeability testing can become routine and widely used. Here, we have developed a one-component system comprising of a naphthyl-pyridine core coupled to a boronic acid receptor, which can be used for early detection of saccharide biomarkers (i.e., lactulose) for applications related to GI barrier dysfunction. For quantitation of lactulose as a model biomarker, we have designed gold nanoparticle decorated surfaces in a highly scalable 96-well format to enable sensitive testing of lactulose within a broad range of concentrations. To tackle current challenges in saccharide biomarker sensing, we developed a hybrid sensing principle integrating two optical modalities (plasmonics and fluorescence) with a synthetic smart-probe (naphthyl-pyridinium) for monitoring GI permeability. This technology can be further developed as an affordable and portable diagnostic tool for GI permeability screening for routine use, facilitating early detection of various diseases affecting the GI tract.

Yazarlar (10)

1
Fatih Inci
2
Angel Resendez
3
Merve Gökşin Karaaslan
4
Mallesh Pandrala
ORCID: 0000-0001-5685-5516
5
Amideddin Mataji Kojouri
6
Rajib Ahmed
7
Mehmet Giray Ogut
8
Bakthan Singaram
9
Sanjay V. Malhotra
ORCID: 0000-0003-4056-5033
10
Utkan Demirci

Anahtar Kelimeler

And sugar markers Fluorescent probe Gastrointestinal barrier dysfunction Gold nanoparticles Sensing principle

Kurumlar

Bilkent Üniversitesi
Ankara Turkey
Oregon Health & Science University
Portland United States
Stanford University School of Medicine
Stanford United States
University of California, Santa Cruz
Santa Cruz United States
Wuhan Textile University
Wuhan China
Scimago Dergi (ISSN Eşleşmesi)
Biosensors and Bioelectronics
Q1
SJR Skoru1,833
H-Index268
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Biomedical Engineering (Q1)
Biophysics (Q1)
Biotechnology (Q1)
Electrochemistry (Q1)
Medicine (miscellaneous) (Q1)
Nanoscience and Nanotechnology (Q1)
Dergi sayfasına git

Metrikler

4
Atıf
10
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

MK
MERVE GÖKŞİN KARAASLAN TUNÇ
Dr. Öğr. Üyesi

Hızlı Erişim

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