Scopus
YÖKSİS Eşleşti
A smart probe for detection of sugar markers for applications in gastrointestinal barrier dysfunction
Biosensors and Bioelectronics · Mart 2025
YÖKSİS Kayıtları
A smart probe for detection of sugar markers for applications in gastrointestinal barrier dysfunction
Biosensors and Bioelectronics · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MERVE GÖKŞİN KARAASLAN TUNÇ →
A SMART PROBE FOR DETECTION OF SUGAR MARKERS FOR APPLICATIONS IN GASTROINTESTINAL BARRIER DYSFUNCTION
Biosensors and Bioelectronics · 2024 SCI
DOKTOR ÖĞRETİM ÜYESİ MERVE GÖKŞİN KARAASLAN TUNÇ →
Makale Bilgileri
DergiBiosensors and Bioelectronics
Yayın TarihiMart 2025
Cilt / Sayfa272
Scopus ID2-s2.0-85213569660
Özet
Gastrointestinal (GI) barrier dysfunction is an early pathogenic event in many complex diseases. Despite the routine applications of invasive tests, saccharide molecules are used noninvasively for assessing GI tract mucosal barrier function. However, currently available methods for quantification of saccharides molecules are costly and laborious. Simplified, reliable, and high-throughput methods are desired so that GI permeability testing can become routine and widely used. Here, we have developed a one-component system comprising of a naphthyl-pyridine core coupled to a boronic acid receptor, which can be used for early detection of saccharide biomarkers (i.e., lactulose) for applications related to GI barrier dysfunction. For quantitation of lactulose as a model biomarker, we have designed gold nanoparticle decorated surfaces in a highly scalable 96-well format to enable sensitive testing of lactulose within a broad range of concentrations. To tackle current challenges in saccharide biomarker sensing, we developed a hybrid sensing principle integrating two optical modalities (plasmonics and fluorescence) with a synthetic smart-probe (naphthyl-pyridinium) for monitoring GI permeability. This technology can be further developed as an affordable and portable diagnostic tool for GI permeability screening for routine use, facilitating early detection of various diseases affecting the GI tract.
Yazarlar (10)
1
Fatih Inci
2
Angel Resendez
3
Merve Gökşin Karaaslan
4
Mallesh Pandrala
ORCID: 0000-0001-5685-5516
5
Amideddin Mataji Kojouri
6
Rajib Ahmed
7
Mehmet Giray Ogut
8
Bakthan Singaram
9
Sanjay V. Malhotra
ORCID: 0000-0003-4056-5033
10
Utkan Demirci
Anahtar Kelimeler
And sugar markers
Fluorescent probe
Gastrointestinal barrier dysfunction
Gold nanoparticles
Sensing principle
Kurumlar
Bilkent Üniversitesi
Ankara Turkey
Oregon Health & Science University
Portland United States
Stanford University School of Medicine
Stanford United States
University of California, Santa Cruz
Santa Cruz United States
Wuhan Textile University
Wuhan China
Metrikler
4
Atıf
10
Yazar
5
Anahtar Kelime