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Role of aspartate aminotransferase to platelet ratio in prediction of intrahepatic cholestasis of pregnancy

Clinical and Experimental Hepatology · Ocak 2024

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YÖKSİS Kayıtları
Role of aspartate aminotransferase to platelet ratio in prediction of intrahepatic cholestasis of pregnancy
Clinical and Experimental Hepatology · 2024 emergency index
PROFESÖR AYBİKE PEKİN →
Role of aspartate aminotransferase to platelet ratioin prediction of intrahepatic cholestasis of pregnancy
Clinical and Experimental Hepatology · 2024 EMERGİNG SCİ
PROFESÖR GÖKÇEN ÖRGÜL →

Makale Bilgileri

DergiClinical and Experimental Hepatology
Yayın TarihiOcak 2024
Cilt / Sayfa10 · 285-290
DOI10.5114/ceh.2024.145447
Scopus ID2-s2.0-85214839153
Erişim🔓 Açık Erişim
Özet Aim of the study: We aimed to compare the first, second and third trimester APRI (aspartate aminotransferase to platelet ratio index) scores in pregnant women with and without intrahepatic cholestasis (ICH). Material and methods: In this study, 54 patients diagnosed with ICH and 59 healthy pregnant women admitted to a tertiary care center between 2018 and 2024 were evaluated. APRI scores were compared between the two groups for three trimesters (first, second, and third trimester). The optimal cut-off values of the APRI score for the prediction of ICH were analyzed. Results: APRI scores were significantly higher in the ICH group in all trimesters (p = 0.028, p < 0.001, p < 0.001, respectively). The optimal cut-off value for APRI score to predict ICH in the first, second, and third trimesters was 0.06 (42.6% sensitivity, 83.1% specificity), 0.1 (57.4% sensitivity, 93.2% specificity) and 13 (77.8% sensitivity, 98.3% specificity), respectively. Conclusions: APRI score was found to be a significant predictor of ICH throughout the entire pregnancy. APRI score seems to be a useful marker in clinical practice to predict ICH.

Yazarlar (5)

1
Nizamettin Bozbay
ORCID: 0000-0001-9632-5093
2
Şeyma Kılıç
3
Osman Yıldırım
4
Aybike Pekin
5
Gökçen Örgül
ORCID: 0000-0003-0578-4230

Anahtar Kelimeler

APRI score bile acids intrahepatic cholestasis pregnancy

Kurumlar

Selçuk Tip Fakültesi
Konya Turkey

Sistemimizdeki Yazarlar

GÖ
GÖKÇEN ÖRGÜL
PROFESÖR

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