Scopus
🔓 Açık Erişim
Relationship between epidermal growth factor receptor gene mutations and clinicopathological features in patients with non-small cell lung cancer in Western Turkey
Asian Pacific Journal of Cancer Prevention · Ocak 2013
Makale Bilgileri
DergiAsian Pacific Journal of Cancer Prevention
Yayın TarihiOcak 2013
Cilt / Sayfa14 · 3705-3709
Scopus ID2-s2.0-84882734849
Erişim🔓 Açık Erişim
Özet
Background: To investigate epidermal growth factor receptor (EGFR) gene mutations in patients with nonsmall cell lung cancer (NSCLC) and to analyze any relationship with clinicopathological features and prognosis. Materials and Methods: EGFR gene exons 18-21 in 48 specimens of paraffin-embedded tumor tissue from NSCLC patients were amplified by PCR, followed by direct sequencing and analysis of links to clinicopathological features and prognosis. Results: EGFR mutations were detected in 18 of 48 (42.6%) patients with NSCLC. There were 9 cases of mutations in exon 20, 7 in exon 19 and 2 in exon 21. Mutations were more frequently observed in women (5/7 pts, 71.4%) than in men (13/41 pts, 31.7%) (p=0.086) and in non-smokers (5/5 pts, 100%) than smokers (13/43 pts, 30.2%). There was negative correlation of EGFR mutations with smoking status (p=0.005). EGFR mutations were more frequently observed with adenocarcinoma histology (13/32 pts, 40.6%) than in other types (5/16 pts, 31.3%) (p=0.527). The patients with EGFR mutations had better survival than those with wildtype EGFR (p=0.08). There was no association of EGFR mutations with metastatic spread. Conclusions: EGFR mutations in NSCLC were here demonstrated more frequently in females, non-smokers and adenocarcinoma histology in the western region of Turkey. Patients with EGFR mutations have a better prognosis.
Yazarlar (9)
1
Olcun Umit Unal
2
Ilhan Oztop
3
Gizem Calibasi
4
Yasemin Baskin
5
Dogan Koca
6
Necla Demir
ORCID: 0000-0003-0927-6962
7
Tulay Akman
8
Hulya Ellidokuz
ORCID: 0000-0001-8503-061X
9
Ahmet Yilmaz
Anahtar Kelimeler
Clinical features
EGFR mutations
Non small cell lung cancer
Western Turkey
Kurumlar
Dokuz Eylül Üniversitesi
Izmir Turkey
İzmir Üniversitesi
Izmir Turkey
Metrikler
24
Atıf
9
Yazar
4
Anahtar Kelime