Scopus
Long-term outcomes and prognostic factors of high-risk malignant melanoma patients after surgery and adjuvant high-dose interferon treatment: A single-center experience
Chemotherapy · Mayıs 2014
Makale Bilgileri
DergiChemotherapy
Yayın TarihiMayıs 2014
Cilt / Sayfa60 · 228-238
Scopus ID2-s2.0-84929946426
Özet
Background: Surgical excision constitutes an important part of the treatment of local advanced malignant melanoma. Due to the high recurrence risk, adjuvant high-dose interferon therapy is still the only therapy used in stage IIB and III high-risk melanoma patients. Methods: One hundred two high-risk malignant melanoma patients who received high-dose interferon-α-2b therapy were evaluated retrospectively. The clinicopathological features, survival times, and prognostic factors of the patients were determined. Results: The median disease-free and overall survival times were 25.2 and 60.8 months, respectively. Our findings revealed that male gender, advanced disease stage, lymph node involvement, lymphatic invasion, the presence of ulceration, and a high Clark level were significant negative prognostic factors. Conclusion: In light of the favorable survival results obtained in this study, high-dose interferon treatment as adjuvant therapy for high-risk melanoma is still an efficient treatment and its possible side effects can be prevented by taking the necessary precautions.
Yazarlar (11)
1
Tulay Akman
2
Ilhan Oztop
3
Ilkay Tugba Unek
4
Dogan Koca
5
Olcun Umit Unal
6
Tarik Salman
7
Tugba Yavuzsen
8
Ahmet Yilmaz
9
Isil Somali
ORCID: 0000-0003-3135-9043
10
Necla Demir
ORCID: 0000-0003-0927-6962
11
Hulya Ellidokuz
ORCID: 0000-0001-8503-061X
Anahtar Kelimeler
Clinicopathological features
Interferon
Melanoma
Prognostic factors
Survival
Treatment
Kurumlar
Ataturk Training and Research Hospital
Izmir Turkey
Atatürk Üniversitesi
Erzurum Turkey
Dokuz Eylül Üniversitesi
Izmir Turkey
Istanbul Hospital
Van Turkey
Medical Park Izmir Hospital
Izmir Turkey
Metrikler
5
Atıf
11
Yazar
6
Anahtar Kelime