Scopus
Clinical Significance of HER2 Overexpression in Gastric and Gastroesophageal Junction Cancers
Journal of Gastrointestinal Surgery · Eylül 2015
Makale Bilgileri
DergiJournal of Gastrointestinal Surgery
Yayın TarihiEylül 2015
Cilt / Sayfa19 · 1565-1571
Scopus ID2-s2.0-84939466651
Özet
Background: In this study, we investigated the rate of human epidermal growth factor receptor 2 (HER2) overexpression in gastric (GC) and gastroesophageal junction cancers (GEJCs) and the relationship with HER2 expression and clinical, pathological parameters and prognosis. Methods: Surgery or biopsy specimen of 598 (436 males, 162 females) patients with GC or GEJC was evaluated for the presence of HER2 overexpression by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) methods. Results: HER2 IHC scores were as follows: 418 (69.9 %) IHC 0, 58 (9.7 %) IHC 1+, 50 (8.4 %) IHC 2+, 72 (12 %) IHC 3+. Among 50 patients with IHC 2+, 18 (38.2 %) were FISH positive, and 29 (61.7 %) were FISH negative for HER2 amplification. Patients were regarded as HER2 positive in case of IHC 3+ disease or IHC 2+ disease with a positive FISH test result for HER2 amplification. In the primary analysis population, 90 (15 %) were considered HER2 positive. HER2 positivity was higher in intestinal GC compared to diffuse GC (16.9 vs 6.6 %, p = 0.014). HER2 positivity was significantly higher in well and moderately differentiated tumors than poorly differentiated tumors (p < 0.0001). HER2 positivity had no significant effect on median OS (23.2 vs 19.1 months, p = 0.44). But in the early stages (stages I and II), median OS of HER2-positive patients was shorter than HER2-negative patients (51.4 months vs not reach, p = 0.047). However, median OS was similar in patients with advanced stages (stages III and IV) HER2-positive and HER2-negative disease (16.2 vs 13.7 months, p = 0.72). Conclusions: Rate of HER2 positivity is similar in Turkish patients with GC and GEJCs. HER2 positivity is associated with poor prognosis in patients with early-stage disease.
Yazarlar (23)
1
Meltem Baykara
2
Mustafa Benekli
3
Ozgur Ekinci
4
Sultan Cigdem Irkkan
5
Halit Karaca
6
Umut Demirci
7
Muhammed Bulent Akinci
8
Olcun Umit Unal
9
Faysal Dane
10
Fatma Paksoy Turkoz
11
Ozan Balakan
12
Eylem Pinar Eser
13
Selcuk Cemil Ozturk
14
Metin Ozkan
15
Berna Öksüzoğlu
16
Alper Sevinc
17
Necla Demir
ORCID: 0000-0003-0927-6962
18
Hakan Harputluoglu
19
Bulent Yalcin
20
Ugur Coskun
21
Aytug Uner
22
Ahmet Ozet
23
Süleyman Büyükberber
Anahtar Kelimeler
GC
GEJCs
HER2
Prognosis
Kurumlar
Ankara Oncology Education and Research Hospital
Ankara Turkey
Ankara Yildirim Beyazit University
Ankara Turkey
Ataturk Training and Research Hospital
Izmir Turkey
Dokuz Eylül Üniversitesi
Izmir Turkey
Erciyes Üniversitesi
Kayseri Turkey
Gaziantep Üniversitesi
Gaziantep Turkey
Gazi Üniversitesi
Ankara Turkey
Inönü Üniversitesi
Malatya Turkey
Marmara Üniversitesi
Istanbul Turkey
Sakarya Üniversitesi
Serdivan Turkey
Metrikler
18
Atıf
23
Yazar
4
Anahtar Kelime