Scopus
YÖKSİS Eşleşti
Characterization of the chemical profiles and biological activities of Thesium bertramii Azn. Extracts using a combination of in vitro, in silico, and network pharmacology methods
Fitoterapia · Ocak 2025
YÖKSİS Kayıtları
Characterization of the chemical profiles and biological activities of Thesium bertramii Azn. Extracts using a combination of in vitro, in silico, and network pharmacology methods
Fitoterapia · 2025 SCI-Expanded
PROFESÖR EVREN YILDIZTUGAY →
Makale Bilgileri
DergiFitoterapia
Yayın TarihiOcak 2025
Cilt / Sayfa180
Scopus ID2-s2.0-85211067331
Özet
The genus Thesium, family Santalaceae, comprises about 350 species, and, although many of them are used as functional food and in traditional medicine, there are limited studies evaluating their pharmacological potential. The present study was designed to evaluate the chemical profile, antioxidant, and enzyme inhibition potential of aerial parts and roots of T. bertramii Azn. Extracts were rich in phenolics: MeOH and aqueous extracts of the aerial parts showed the highest total phenolic and flavonoid contents and the best antioxidant activity in most assays. Ethyl acetate extracts of both organs exerted comparable anti-butyrylcholinesterase activity, while their methanol extracts displayed comparable anti-tyrosinase activity. The highest acetylcholinesterase inhibitory activity was recorded from the root's ethyl acetate extract, while that of the aerial parts revealed the best α-amylase and α-glucosidase inhibitory activity. Chemically, the aerial parts were dominated by quercetin derivatives, feruloylquinic acids, caffeoylquinic acids, and elenolic acid glucoside. Roots showed a lower diversity of compounds with elenolic acid, quercetin glycoside, and kaempferol glycoside as major compounds. Additionally, network pharmacology analyses (KEGG and STRING) identified critical molecular pathways and hub genes, including IL6, TNF, BCL-2, and JUN, indicating the multi-target potential of T. bertramii in cancer and cardiovascular diseases. In conclusion, this study assessed the chemical and biological properties of T. bertramii for the first time, and the obtained results indicated the potential of this species as a valuable source of bioactive molecules for the pharmaceutical, food, and cosmetic industries.
Yazarlar (9)
1
E. J. Llorent-Martínez
2
Sakina Yagi
3
Gokhan Zengin
ORCID: 0000-0001-6548-7823
4
Mehmet Veysi Cetiz
ORCID: 0000-0002-2635-6553
5
Abdullahi Ibrahim Uba
6
Ozgur Yuksekdag
7
Bengusu Hacer Akgul
8
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
9
Ismail Koyuncu
Anahtar Kelimeler
Antioxidant, enzyme inhibition
Chemical profile
Network pharmacology
Thesium bertramii
Kurumlar
Biozentrum der Universität Würzburg
Wurzburg Germany
Harran University, Faculty of Medicine
Sanliurfa Turkey
İstanbul Arel Üniversitesi
Istanbul Turkey
Khartoum University
Khartoum Sudan
Selçuk Üniversitesi
Selçuklu Turkey
Universidad de Jaén
Jaen Spain
Université de Lorraine
Nancy France