Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
Revista Cientifica de la Facultad de Veterinaria · Ocak 2024
YÖKSİS Kayıtları
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
Revista Científica de la Facultad de Ciencias Veterinarias · 2024 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ SEDA ŞİMŞEK →
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
Revista Científica de la Facultad de Ciencias Veterinarias · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ NEJAT ÜNLÜKAL →
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
Revista Científica de la Facultad de Ciencias Veterinarias · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUSLU KAZIM KÖREZ →
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
Revista Científica de la Facultad de Ciencias Veterinarias · 2024 SCI-Expanded
PROFESÖR ENDER ERDOĞAN →
Makale Bilgileri
DergiRevista Cientifica de la Facultad de Veterinaria
Yayın TarihiOcak 2024
Cilt / SayfaXXXIV
Scopus ID2-s2.0-85214371385
Erişim🔓 Açık Erişim
Özet
As a result of the increasing use of quantum dots (QDs) and increased exposure of human beings to quantum dots, the study of the toxicity of the particles has become an important issue. In this study, the protective activity of silymarin and mitoquinone (MitoQ), which are known to have antioxidant properties, on the histopathological and biochemical changes observed in the liver of mice treated with CdTe QDs was investigated. 26 male Swiss mice were randomly divided into four groups: Control (G1), CdTe QDs (G2), silymarin + CdTe QDs (G3), mitoquinone + CdTe QDs (G4) application groups. Animals were sacrificed 24 hours (h) after injections and hyperspectral microscopy images were obtained. According to the ICP–MS results, the CdTe QDs injected through the tail vein accumulated in the liver at the end of 24 h and caused tissue damage according to the hematoxylin & eosin examination, and better preservation was observed with the antioxidant pre–treatment. The immunofluorescence results showed increased inflammation and apoptosis in the QDs group. It was observed that silymarin and mitoquinone decreased anti–MMP–9, anti–IL–10, anti–IL–1b, anti–TNF–α, and anti–caspase–9, TUNEL– positive cell ratio, liver MDA levels. There was no significant difference in serum TAS (P=0.509), TOS (P=0.588) levels, but antioxidants also increased tissue SOD and CAT levels. Antioxidants had no significant effect on anti–MT–MMP2 and anti–caspase–8 levels (P<0.001). In conclusion, it was shown that pretreatment of CdTe QD–administered mice with silymarin and mitoquinone can reduce oxidative stress in liver tissue and may have a protective effect through reduction of apoptosis and inflammation.
Yazarlar (6)
1
S. Şimsek
2
Merve Solmaz
3
İsmail Hakkı Nur
ORCID: 0000-0001-7215-8112
4
M. K. Korez
ORCID: 0000-0001-9524-6115
5
Nejat Ünlükal
ORCID: 0000-0002-8107-4882
6
Ender Erdoğan
Anahtar Kelimeler
Antioxidant
mitoquinone
oxidative stress
quantum dot
silymarin
Kurumlar
Erciyes Üniversitesi
Kayseri Turkey
Selçuk Üniversitesi
Selçuklu Turkey