Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Impaired Kynurenine Pathway in Inflammatory Bowel Disease
Journal of Clinical Medicine · Ekim 2024
YÖKSİS Kayıtları
Impaired Kynurenine Pathway in Inflammatory Bowel Disease
Journal of Clinical Medicine · 2024 SCI-Expanded
PROFESÖR HÜSAMETTİN VATANSEV →
Impaired Kynurenine Pathway in Inflammatory Bowel Disease
Journal of Clinical Medicine · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUSLU KAZIM KÖREZ →
Makale Bilgileri
DergiJournal of Clinical Medicine
Yayın TarihiEkim 2024
Cilt / Sayfa13
Scopus ID2-s2.0-85207597285
Erişim🔓 Açık Erişim
Özet
Background/Objectives: Inflammatory bowel diseases primarily encompass Crohn’s disease and ulcerative colitis. Insufficient levels of tryptophan cause an imbalance in the gut microbiota, leading to inflammation in the gastrointestinal tract. The main catabolic pathway of tryptophan is the kynurenine pathway. Our study aims to evaluate serum tryptophan, the kynurenine pathway, and oxidative stress parameters, including total oxidant status and total antioxidant capacity, in patients with Crohn’s disease and ulcerative colitis. Methods: The study included 80 follow-up patients in remission diagnosed with Crohn’s disease and ulcerative colitis who attended the Gastroenterology Outpatient Clinic, as well as 78 healthy controls. Serum tryptophan, kynurenine, 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and kynurenic acid levels were measured with liquid chromatography and tandem mass spectrometry (LC-MS/MS). All statistical analysis was performed using R version 4.2.1. Statistical Language. Results: Serum tryptophan, 3-hydroxyanthranilic acid, and total antioxidant capacity were lower in patients with ulcerative colitis and Crohn’s disease compared to those in the control group. The serum total oxidant status in the control group was significantly lower than in patients with Crohn’s disease and ulcerative colitis. Conclusions: The results of our research indicate that tryptophan and kynurenine pathway metabolites could potentially contribute to the pathogenesis of inflammatory bowel diseases.
Yazarlar (7)
1
Esra Paydas Hataysal
ORCID: 0000-0002-3538-8135
2
M. K. Korez
ORCID: 0000-0001-9524-6115
3
Eray Metin Guler
ORCID: 0000-0003-4351-1719
4
Hakan Vatansev
ORCID: 0000-0002-1095-6802
5
Kubra Bozalı
ORCID: 0000-0003-2416-0773
6
Metin Basaranoglu
7
Hüsamettin Vatansev
Anahtar Kelimeler
Crohn’s disease
inflammatory bowel diseases
kynurenine pathway
tryptophan
ulcerative colitis
Kurumlar
Bezmiâlem Vakıf Üniversitesi
Istanbul Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey
University of Health Sciences
Istanbul Turkey
Yalçın City Hospital
Istanbul Turkey
Metrikler
3
Atıf
7
Yazar
5
Anahtar Kelime