Scopus
YÖKSİS Eşleşti
Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Outcomes of survival, toxicity, sphincter preserving and prognostic factors
Transplant Immunology · Aralık 2021
YÖKSİS Kayıtları
Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Outcomes of survival, toxicity, sphincter preserving and prognostic factors
Transplant Immunology · 2021 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUSLU KAZIM KÖREZ →
Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Outcomes of survival, toxicity, sphincter preserving and prognostic factors.
Transplant immunology · 2021 SCI
PROFESÖR ORHAN ÖNDER EREN →
Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Outcomes of survival, toxicity, sphincter preserving and prognostic factors
Transplant Immunology · 2021 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MÜRSEL DÜZOVA →
Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Outcomes of survival, toxicity, sphincter preserving and prognostic factors.
Transplant immunology · 2021 SCI
DOKTOR ÖĞRETİM ÜYESİ MÜRSEL DÜZOVA →
Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Outcomes of survival, toxicity, sphincter preserving and prognostic factors
Transplant Immunology · 2021 SCI-Expanded
DOÇENT HAMİT BAŞARAN →
Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Outcomes of survival, toxicity, sphincter preserving and prognostic factors
Transplant Immunology · 2021 SCI-Expanded
DOÇENT OSMAN VEFA GÜL →
Makale Bilgileri
DergiTransplant Immunology
Yayın TarihiAralık 2021
Cilt / Sayfa69
Scopus ID2-s2.0-85117780365
Özet
Background: This study aimed to compare preoperative chemoradiotherapy (CRT) with postoperative CRT regarding survival, local control, disease control, sphincter preservation, toxicity and also prognostic factors for the treatment of locally advanced rectal cancer. Methods: Records of 140 patients with locally advanced rectal cancer who received preoperative or postoperative CRT were analyzed retrospectively. We compared the treatment groups (preoperative vs postoperative) according to baseline characteristics (demographic and rectal cancer disease characteristics), and also carried out the survival analyses. Results: From January 2010 to December 2019, 140 patients were included in the analysis, 65 received preoperative treatment and 75 postoperative treatment. There was no difference in survival, recurrence or distant metastasis rate in both treatment groups. The ratios of the failure to complete adjuvant chemotherapy (32% vs 4.6%) and acute grade 3–4 toxicity (32% vs 6.2%) were higher in the postoperative group (p < 0.001). In lower located tumors (≤5 cm from anal verge) the ratio of the sphincter preserving in the preoperative group was 60.7% (n = 17/28), and was 16.6% (n = 3/18) in the postoperative group (Yates χ2 = 5.829, p = 0.005). Conclusion: This study showed no difference in recurrence and survival rate. Preoperative CRT is the preferred treatment for patients with locally advanced rectal cancer, given that it is associated with a superior overall treatment compliance rate, reduced toxicity, and an increased rate of sphincter preservation in low-lying tumors, but not for overall survival.
Yazarlar (6)
1
Mursel Duzova
2
Hamit Basaran
3
Gokcen Inan
ORCID: 0000-0003-2995-0256
4
Osman Vefa Gul
ORCID: 0000-0002-6773-3132
5
Orhan Onder Eren
6
M. K. Korez
ORCID: 0000-0001-9524-6115
Anahtar Kelimeler
Locally advanced rectal cancer
Postoperative chemoradiotherapy
Preoperative chemoradiotherapy
Prognostic factors
Survival
Toxicity
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
5
Atıf
6
Yazar
6
Anahtar Kelime