Scopus
YÖKSİS Eşleşti
Assessment of the cardiotoxicity of tulathromycin in rabbits
Acta Veterinaria Hungarica · Eylül 2011
YÖKSİS Kayıtları
ASSESSMENT OF THE CARDIOTOXICITY OF TULATHROMYCIN IN RABBITS
ACTA VETERINARIA HUNGARICA · 2011 SCI-Expanded 37 atıf
PROFESÖR MUAMMER ELMAS →
Assessment of the cardiotoxicity of tulathromycin in rabbits
Acta Veterinaria Hungarica · 2011 SCI
PROFESÖR AYŞE ER →
ASSESSMENT OF THE CARDIOTOXICITY OF TULATHROMYCIN IN RABBITS
ACTA VETERINARIA HUNGARICA · 2011 SCI-Expanded
PROFESÖR BURAK DİK →
Assessment of the cardiotoxicity of tulathromycin in rabbits
Acta Veterinaria Hungarica · 2011 SSCI
PROFESÖR ENVER YAZAR →
Makale Bilgileri
DergiActa Veterinaria Hungarica
Yayın TarihiEylül 2011
Cilt / Sayfa59 · 327-335
Scopus ID2-s2.0-79960285290
Özet
The aim of this study was to determine the cardiotoxic potency of tulathromycin. Tulathromycin (10 mg/kg, SC) was administered to ten adult male rabbits, and blood samples were obtained before and after drug administration (0 and 6 hours). Serum cardiac damage markers (troponin I, creatine kinase-MB, myoglobin, lactate dehydrogenase, aspartate aminotransferase), routine serum biochemical values (alkaline phosphatase, alanine aminotransferase, gamma-glutamyltransferase, creatinine, blood urea nitrogen, cholesterol, triglyceride, high-density lipoprotein, amylase, total protein, albumin, glucose, calcium, ionised calcium, sodium, potassium), white blood cell (WBC) and red blood cell (RBC) counts, arterial blood gas parameters (pH, partial carbon dioxide pressure, partial oxygen pressure, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, packed cell volume, haemoglobin) and serum oxidative status (malondialdehyde, nitric oxide, superoxide dismutase, retinol, β-carotene) were measured. Increased levels of troponin I, creatine kinase-MB and creatinine, and decreased WBC counts, ionised calcium and potassium levels were observed after drug administration. Tulathromycin treatment may cause cardiotoxicity, but its effects may be less dramatic than those of other macrolide antibiotics frequently used in veterinary medicine.
Yazarlar (6)
1
A. Er
2
Feray Altan
3
Gul Cetin
4
Burak Dik
5
M. Elmas
6
E. Yazar
Anahtar Kelimeler
cardiotoxicity
Tulathromycin
Kurumlar
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Dicle Üniversitesi
Diyarbakir Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
15
Atıf
6
Yazar
2
Anahtar Kelime