Scopus
YÖKSİS Eşleşti
Corynebacterium cutis Lysate Treatment Can Increase the Efficacies of PPR Vaccine
Journal of Interferon and Cytokine Research · Ekim 2016
YÖKSİS Kayıtları
Corynebacterium Cutis Lysate Treatment can Increase the Efficacies of PPR Vaccine
Journal of Interferon & Cytokine Research · 2016 SCI-Expanded
DOÇENT IRMAK DİK →
Corynebacterium cutis Lysate Treatment Can Increase the Efficacies of PPR Vaccine
Journal of Interferon & Cytokine Research · 2016 SCI-Expanded
PROFESÖR OĞUZHAN AVCI →
Corynebacterium cutis Lysate Treatment Can Increase the Efficacies of PPR Vaccine
Journal of Interferon & Cytokine Research · 2016 SCI-Expanded
PROFESÖR OĞUZHAN AVCI →
Corynebacterium cutis Lysate Treatment Can Increase the Efficacies of PPR Vaccine
Journal of Interferon Cytokine Research · 2016 SCI
PROFESÖR BURAK DİK →
Makale Bilgileri
DergiJournal of Interferon and Cytokine Research
Yayın TarihiEkim 2016
Cilt / Sayfa36 · 599-606
Scopus ID2-s2.0-84990031873
Özet
This study aimed to evaluate the effects of Peste des petits ruminants (PPR) vaccine on cytokine and antibody levels in sheep when administered alone or in combination with Corynebacterium cutis lysate (CCL). The PPR vaccine group received a single subcutaneous axillary injection of the PPR vaccine (1 mL containing tissue culture infectious dose (TCID)50 attenuated live PPRV, n = 6) and the combination treatment (1 mL CCL and 1 mL PPR vaccine, n = 6) groups received a single subcutaneous axillary injection of both CCL and PPR vaccine. Blood samples were collected from sheep before the treatment and at different points after treatment (1, 3, 7, 14, 21, and 28 days). Plasma and serum samples were evaluated for antibody percentage, levels of cytokines IL-6, IL-10, IFN-γ, IL-4, IL-12, and IL-18, oxidative stress marker Thiobarbituric acid reactive substances, and hematological and biochemical parameters. Maximum protective antibody levels reach 3-4 weeks after vaccine administration. The combination treatment resulted in significant changes in IFN-γ, IL-4, IL-12, and IL-18 cytokine levels. These changes were not evident when only the PPR vaccine was administered and antibody percentage against PPRV was short term in PPR vaccine group. In conclusion, combined usage of the PPR vaccine with CCL resulted in a heightened cytokine response, leading to improved antibody level against PPR virus. Repeated CCL treatments can lead to earlier vaccine potency, provide protective efficacy for a longer time, and increase passive immunity.
Yazarlar (4)
1
Burak Dik
2
Irmak Dik
ORCID: 0000-0003-2516-9489
3
Emre Bahcivan
4
Oğuzhan Avci
ORCID: 0000-0001-9299-4695
Anahtar Kelimeler
Corynebacterium cutis lysate
Cytokine
Interferon
Peste des petits ruminants
Vaccine effectiveness
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
4
Atıf
4
Yazar
5
Anahtar Kelime