Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Effects of BCRP and P-gp modulators on the penetration of aflatoxin B<inf>1</inf> into the mouse brain
Kafkas Universitesi Veteriner Fakultesi Dergisi · Ocak 2017
YÖKSİS Kayıtları
Aflatoksin B1’in Fare Beynine Geçişi Üzerine BCRP ve P-gp Modülatörlerinin Etkisi
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2017 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Effects of BCRP and P-gp Modulators on the Penetration of Aflatoxin B-1 into the Mouse Brain
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2017 SCI-Expanded
PROFESÖR BURAK DİK →
Aflatoksin B1’in Fare Beynine Geçişi Üzerine BCRP ve P-gp Modülatörlerinin Etkisi
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2017 SCI-Expanded
PROFESÖR BÜNYAMİN TRAŞ →
Makale Bilgileri
DergiKafkas Universitesi Veteriner Fakultesi Dergisi
Yayın TarihiOcak 2017
Cilt / Sayfa23 · 95-100
Scopus ID2-s2.0-84993990705
Erişim🔓 Açık Erişim
Özet
This study was conducted to determine whether the plasma and brain concentrations of AFB1 are affected by the modulation of P-gp and BCRP using zosuquidar (ZQR) and prazosin (PRZ), respectively. In this study, a total of 40 healthy adult male BALB/c mice (32±3.7 g) were used. The animals were randomly divided into 5 groups, with 8 animals per group. Group 1 was used for method validation. Group 2 (AF) received intraperitoneal AFB1 at a dose of 20 mg/kg of body weight. Groups 3 (AF+PRZ), 4 (AF+ZQR), and 5 (AF+PRZ+ZQR) received 20 mg/kg of AFB1 intraperitoneally 30 min after the intraperitoneal administration of prazosin (0.3 mg/kg), zosuquidar (25 mg/kg), and prazosin+zosuquidar (0.3 mg/kg prazosin + 25 mg/kg zosuquidar), respectively. Six hours after the administration of AFB1, blood and brain samples were collected from the animals in Groups 2 to 5. AFB1 concentrations were determined using an HPLC system with fluorescence detection. Individual and simultaneous administration of prazosin and zosuquidar significantly reduced the brain concentrations of AFB1 in comparison to a single administration of AFB1 (P<0.05). The brain/plasma ratio of the AF group was higher than that of the other groups (AF+PRZ, AF+ZQR, and AF+PRZ+ZQR) (P<0.05). Inducers of transmembrane proteins, especially BCRP, can be life saving during acute AFB1 poisoning.
Yazarlar (6)
1
B. Traş
2
Gul Cetin
3
Kamil Üney
ORCID: 0000-0002-8674-4873
4
Burak Dik
5
Orhan Corum
ORCID: 0000-0003-3168-2510
6
Sema Atalay
Anahtar Kelimeler
Aflatoxin B 1
Brain
Drug transporter proteins
Mice
Modulation
Kurumlar
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Dicle Üniversitesi
Diyarbakir Turkey
Energy Inc.
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
5
Atıf
6
Yazar
5
Anahtar Kelime