Scopus
YÖKSİS Eşleşti
Comparative evaluation of single and combined efficacy of dipyridamole, ketotifen and quercetin on cyclosporine induced hepatorenal toxicity
Polish Journal of Veterinary Sciences · Ocak 2023
YÖKSİS Kayıtları
Comparative evaluation of single and combined efficacy of dipyridamole, ketotifen and quercetin on cyclosporine induced hepatorenal toxicity
Polish Journal of Veterinary Sciences · 2023 SCI-Expanded
PROFESÖR AYŞE ER →
Comparative evaluation of single and combined efficacy of dipyridamole, ketotifen and quercetin on cyclosporine induced hepatorenal toxicity
Polish Academy of Sciences Chancellery · 2023 SCI-Expanded
PROFESÖR BURAK DİK →
Comparative evaluation of single and combined efficacy of dipyridamole, ketotifen and quercetin on cyclosporine induced hepatorenal toxicity
Polish Journal of Veterinary Sciences · 2023 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ TUĞBA MELİKE PARLAK →
Makale Bilgileri
DergiPolish Journal of Veterinary Sciences
Yayın TarihiOcak 2023
Cilt / Sayfa26 · 549-557
Scopus ID2-s2.0-85179637698
Özet
Cyclosporine is an immunosuppressive drug that is used to prevent tissue rejection in organ transplants and to treat autoimmune diseases such as psoriasis and rheumatoid arthritis. It has important toxic effects in many organs such as the liver and kidney. The aim of this study was to determine and compare the effectiveness of the single and combined treatment of dipyridamole, which is a vasodilator and has an antioxidant effect, ketotifen which is toll-like receptor-4 inhibitory and has an antioxidant effect, quercetin which is an antioxidant and has an anti-inflammatory effect in cyclosporine-induced hepatorenal toxicity. Forty-eight Wistar Albino rats were divided into 7 groups. The research period was 21 days. The cyclosporine increased serum ALT and AST levels, in contrast to their increased levels prevented by all the treatments. The serum creatinine level decreased significantly with ketotifen and combined treatment, while cyclosporine partially increased serum creatinine and urea levels. The urine microalbumin and protein levels were increased significantly by cyclosporine, whereas they decreased with dipyridamole treatment. The protein levels decreased by quercetin and combined treatments. The kidney injury molecule-1 and retinol-binding protein levels were increased by the cyclosporine, while ketotifen treatment partially decreased them. In conclusion, ketotifen and dipyridamole can prevent cyclosporine-induced hepatorenal toxicity and quercetin can increase the effectiveness of this treatment.
Yazarlar (5)
1
Burak Dik
2
T. M. Parlak
3
Oznur Tufan
4
F. B. Ozgur
5
A. Er
Anahtar Kelimeler
cyclosporine
dipyridamole
hepatorenal toxicity
ketotifen
quercetin
Kurumlar
Harran Üniversitesi
Sanliurfa Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
5
Yazar
5
Anahtar Kelime