Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q1
The Effect of the Combination of Peste Des Petits Ruminants (PPR) Vaccine with Different Doses of Lentinan on Cytokines and Antibody Levels of Sheep
Pakistan Veterinary Journal · Ocak 2023
YÖKSİS Kayıtları
The Effect of the Combination of Peste Des Petits Ruminants (PPR) Vaccine with Different Doses of Lentinan on Cytokines and Antibody Levels of Sheep
Pakistan Veterinary Journal · 2023 SCI-Expanded
Prof. Dr. BURAK DİK →
The Effect of the Combination of Peste Des Petits Ruminants (PPR) Vaccine with Different Doses of Lentinan on Cytokines and Antibody Levels of Sheep
Pakistan Veterinary Journal · 2023 SCI-Expanded
Doç. Dr. IRMAK DİK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Clinical Comparison of Medetomidine with Isoflurane or Sevoflurane for Anesthesia in Horses
2015 ISSN: 0253-8318 SSCI
Prof. Dr. MUSTAFA ARICAN →
Bacillus anthracis isolated from a dog in Turkey
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. ÖZGÜR ÖZDEMİR →
A Retrospective Study of Fractures in Neonatal Calves 181 Cases 2002 2012
2013 ISSN: 0253-8318 SCI-Expanded Q3
Doç. Dr. KURTULUŞ PARLAK →
Effect of Different Storage Temperatures on the Stability of Bovine Viral Diarrhea Virus BVDV RNA in Blood Samples
2015 ISSN: 0253-8318 SCI-Expanded Q3
Doç. Dr. IRMAK DİK →
The investigation of bovine viral diarrhoea virus antigens with immunofluorescence and immunohistochemical methods in bovine abortions
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Effect of different storage temperatures on the stability of bovine viral diarrhea virus RNA in blood samples
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. ATİLLA ŞİMŞEK →
Effect of Different Storage Temperatures on the Stability of Bovine Viral Diarrhea Virus BVDV RNA in Blood Samples
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. SİBEL YAVRU →
Bacillus anthracis Isolated from a Dog in Turkey
2015 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. OSMAN ERGANİŞ →
Bacillus anthracis Isolated from a Dog in Turkey
2015 ISSN: 0253-8318 SCI-Expanded
Doç. Dr. ASLI BALEVİ →
Genotypic Characterization of Bordetella bronchiseptica Strains Isolated from Stray and PetDogs
2016 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. UÇKUN SAİT UÇAN →
Quantification of mitral regurgitation in Anatolian Shepherd Dogs with aseymtomatic degenerative mitral valve disease
2016 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. HASAN GÜZELBEKTEŞ →
Genotypic Characterization of Bordetella bronchiseptica Strains Isolated from Stray and Pet Dogs
2016 ISSN: 0253-8318 SCI-Expanded
Doç. Dr. ASLI BALEVİ →
In Vitro Activity of Toxin Binders on Aflatoxin B1 in Poultry Gastrointestinal Medium
2018 ISSN: 0253-8318 SCI-Expanded
Prof. Dr. HALİS UĞUZ →
Digit Bones (Acropodium) of Gazella (Gazella subgutturosa); Three-Dimensional Modelling
and Morphometry
2021 ISSN: 0253-8318 SCI-Expanded Q3
Prof. Dr. MUSTAFA ORHUN DAYAN →
Predominancy of Rhipicephalus turanicus in Tick-infested Sheep from Turkey: a Large-scale Survey
2021 ISSN: 0253-8318 SCI-Expanded Q3
Doç. Dr. ALİ USLU →
Serological Investigation of Some Vector-Borne Parasitic and Rickettsial Agents in Dogs in the Western Part of Turkey
2021 ISSN: 0253-8318 SCI-Expanded Q1
Doç. Dr. ALİ USLU →
Serological Investigation of Some Vector-Borne Parasitic and Rickettsial Agents in Dogs in the Western Part of Turkey
2021 ISSN: 0253-8318 SCI-Expanded Q3
Prof. Dr. FERDA SEVİNÇ →
Predominancy of Rhipicephalus turanicus in Tick-infested Sheep from Turkey: a Large-scale Survey
2021 ISSN: 0253-8318 SCI-Expanded Q3
Prof. Dr. FERDA SEVİNÇ →
Digit Bones (Acropodium) of Gazella (Gazella subgutturosa); Three-Dimensional Modelling and Morphometry
2021 ISSN: 0253-8318 SCI-Expanded Q3
Dr. Öğr. Üyesi SEDAT AYDOĞDU →
Makale Bilgileri
ISSN02538318
Yayın TarihiOcak 2023
Cilt / Sayfa43 · 683-688
Scopus ID2-s2.0-85181707992
Erişim🔓 Açık Erişim
Özet
Peste des Petits Ruminants (PPR) is an acute contagious viral disease in small ruminants. New methods and adjuvants are needed to increase the immunological potential of the vaccines used and to prolong the duration of action. The aim of this research is to determine the effectiveness of the combination of different doses of lentinan and PPR vaccine on total antibody and some cytokines levels in sheep. For this purpose, 21 sheep were randomly divided into 3 equal groups and the groups were designed as PPR vaccine control, PPR vaccine+Low dose lentinan (5 mg dose, i.v.) and PPR vaccine+High dose lentinan (10 mg dose i.v.). The immunological and hematological parameters were analyzed in all groups before the first application (0. hour) and on the 7th, 14th, 21st, 30th, 45th, 60th, 75th and 90th days. Antibody levels against PPR appears to be positive after 7 days in all groups. However, the antibody level in the PPR+Lent5 group increased partially on the 30th, 60th and 90th days as compared to the PPR group. In addition, the antibody level in the PPR+Lent5 group tends to increase although the antibody level of PPR vaccine group tends to decrease on the 30th day. IL-6, IL-10, IL-4, IFN-γ levels were induced due to the stimulation of Th1 and Th2 cells by different doses of lentinan at different times. In conclusion, lentinan can be a beneficial adjuvant/supporting agent for vaccines. However, more detailed research is needed for different durations, and in different pharmaceutical forms and doses of lentinan.
Yazarlar (4)
1
Irmak Dik
ORCID: 0000-0003-2516-9489
2
H. Furkan Orbay
3
F. B. Ozgur
4
Burak Dik
Anahtar Kelimeler
Antibody
Cytokine
Lentinan
PPR
Vaccine
Kurumlar
Harran Üniversitesi
Sanliurfa Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Pakistan Veterinary Journal
Q1
OA
SJR Skoru0,845
H-Index44
YayıncıUniversity of Agriculture
ÜlkePakistan
Veterinary (miscellaneous) (Q1)
Metrikler
5
Atıf
4
Yazar
5
Anahtar Kelime