Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Potential effects of Resatorvid and alpha lipoic acid on gentamicin-induced nephrotoxicity in rats
Pharmacology Research and Perspectives · Ağustos 2024
YÖKSİS Kayıtları
Potential effects of Resatorvid and alpha lipoic acid on gentamicin‐induced nephrotoxicity in rats
Pharmacology Research & Perspectives · 2024 SCI-Expanded
DOÇENT DURMUŞ HATİPOĞLU →
Potential effects of Resatorvid and alpha lipoic acid on gentamicin‐induced nephrotoxicity in rats
Pharmacology Research & Perspectives · 2024 SCI-Expanded
PROFESÖR BURAK DİK →
Potential effects of Resatorvid and alpha lipoic acid on gentamicin‐induced nephrotoxicity in rats
Pharmacology Research & Perspectives · 2024 SCI-Expanded
DOÇENT MEHMET BURAK ATEŞ →
Makale Bilgileri
DergiPharmacology Research and Perspectives
Yayın TarihiAğustos 2024
Cilt / Sayfa12
Scopus ID2-s2.0-85198071938
Erişim🔓 Açık Erişim
Özet
Gentamicin is an aminoglycoside antibiotic with a rapid bactericidal effect on the treatment of many infections. However, its use at high concentrations for more than 7 days causes nephrotoxic side effects. This study investigated the potential of Resatorvid and alpha lipoic acid (ALA) in mitigating gentamicin-induced nephrotoxicity in rats, considering biochemical, histopathological, and molecular parameters. This study randomly distributed 34 Wistar albino rats into four groups: healthy control (n = 6), Gentamicin (80 mg/kg, n = 7), Gentamicin + Sham (%10 hydroalcoholic solution, n = 7), Gentamicin + Resatorvid (5 mg/kg, n = 7), and Gentamicin + ALA (100 mg/kg, n = 7). Resatorvid treatment led to a statistically significant decrease in urinary IL-18, KIM-1, and NGAL levels, whereas ALA treatment significantly reduced KIM-1 levels compared to the gentamicin-only group. Both Resatorvid and ALA showed partial reductions in urine creatinine levels. Moreover, treatments with Resatorvid and ALA resulted in statistically significant decreases in NRF-2, CAS-3, and NR4A2 expressions. However, only Resatorvid demonstrated a statistically significant decrease in NF-B expression. These findings highlight the potential of Resatorvid in ameliorating gentamicin-induced nephrotoxicity, thereby expanding the therapeutic utility of gentamicin and enhancing its efficacy against infections.
Yazarlar (3)
1
Burak Dik
2
Durmus Hatipoglu
ORCID: 0000-0003-3790-7821
3
Mehmet Burak Ates
ORCID: 0000-0003-1297-426X
Anahtar Kelimeler
alpha lipoic acid
gentamicin
nephrotoxicity
Resatorvid
TLR4
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
3
Yazar
5
Anahtar Kelime