Scopus
YÖKSİS Eşleşti
Impacts of potential anticancer agents based on pillar[5]arene for head and neck squamous cell carcinoma cells
Journal of Cancer Research and Clinical Oncology · Eylül 2023
YÖKSİS Kayıtları
Impacts of potential anticancer agents based on pillar[5]arene for head and neck squamous cell carcinoma cells
Journal of Cancer Research and Clinical Oncology · 2023 SCI-Expanded
PROFESÖR MUSTAFA ÖZMEN →
Impacts of potential anticancer agents based on pillar[5]arene for head and neck squamous cell carcinoma cells
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY · 2023 SCI-Expanded
PROFESÖR AHMED NURİ KURŞUNLU →
Makale Bilgileri
DergiJournal of Cancer Research and Clinical Oncology
Yayın TarihiEylül 2023
Cilt / Sayfa149 · 8711-8718
Scopus ID2-s2.0-85156091861
Özet
Purpose: This study was conducted to investigate impacts of potential anticancer (associated with apoptosis and caspase pathways) of two newly synthesized derivatives of pillar[5]arene, named as d-Q-P5 and p-Q-P5, on Squamous cell carcinomas of the head and neck (HNSCC) cells. Materials and methods: The MTT method was used to determine the IC50 doses of the derivatives on HNSCC cells, and the changes in gene expression were analyzed by real-time polymerase chain reaction (qPCR). The apoptosis change was confirmed by flow cytometry analysis. Results: The results showed that the d-Q-P5 and p-Q-P5 effectively inhibited the proliferation of the cells by upregulating proapoptotic genes (Bax, Bad, p53, Bak, and Apaf-1) and genes involved in the caspase pathway (Casp2, Casp3, and Casp9), while downregulating the antiapoptotic gene (Bcl-2). Conclusions: This study is the first to demonstrate the potential anticancer effects of these two agents on HNSCC cells by positively regulating apoptosis gene expression.
Yazarlar (5)
1
Serkan Kuccukturk
2
Mehmet Ali Karaselek
3
Tugce Duran
ORCID: 0000-0002-7353-4527
4
Ahmed Nuri Kursunlu
5
Mustafa Ozmen
ORCID: 0000-0001-5117-9168
Anahtar Kelimeler
Apoptosis
Caspase
Head and neck squamous cell carcinoma
Pillar[5]arene
Kurumlar
Karamanoğlu Mehmetbey Üniversitesi
Karaman Turkey
Karatay Üniversitesi
Konya Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
5
Yazar
4
Anahtar Kelime