Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Water-soluble Pillar[5]arene-based drug candidates for lung and breast cancer
Journal of Biomolecular Structure and Dynamics · Ocak 2025
YÖKSİS Kayıtları
Water-soluble Pillar[5]arene-based drug candidates for lung and breast cancer
Journal of Biomolecular Structure and Dynamics · 2025 SCI-Expanded
Prof. Dr. MUSTAFA ÖZMEN →
Water-soluble Pillar[5]arene-based drug candidates for lung and breast cancer
Journal of Biomolecular Structure and Dynamics · 2025 SCI-Expanded
Prof. Dr. AHMED NURİ KURŞUNLU →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Biologically active compounds from two members of the Asteraceae family:Tragopogon dubius Scop. and Tussilago farfara L.
2018 ISSN: 0739-1102 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Formation of the Inclusion Complex of Water Soluble Fluorescent Calix[4]arene and Naringenin: Solubility, Cytotoxic effect and Molecular Modeling Studies
2019 ISSN: 0739-1102 SCI
Prof. Dr. MUSTAFA YILMAZ →
Biologically active compounds from two members of the Asteraceae family: Tragopogon dubius Scop. and Tussilago farfara L.
2019 ISSN: 0739-1102 SCI
Prof. Dr. GÖKHAN ZENGİN →
Formation of the inclusion complex of water soluble fluorescent calix[4]arene and naringenin: solubility, cytotoxic effect and molecular modeling studies
2020 ISSN: 0739-1102 SCI-Expanded Q2
Prof. Dr. SERDAR KARAKURT →
Enzyme inhibitory potential of some indole Schiff bases on acetylcholinesterase and human carbonic anhydrase isoforms I and II enzymes: an
in vitro and
molecular docking study
2023 ISSN: 0739-1102 SCI-Expanded Q3
Doç. Dr. HANİF ŞİRİNZADE →
Water-soluble Pillar[5]arene-based drug candidates for lung and breast cancer
2025 ISSN: 0739-1102 SCI-Expanded Q1
Prof. Dr. MUSTAFA ÖZMEN →
Development of a novel apigenin prodrug programmed for alkaline-phosphatase instructed self-inhibition to combat cancer
2023 ISSN: 0739-1102 SCI
Prof. Dr. SERDAR KARAKURT →
Makale Bilgileri
ISSN07391102
Yayın TarihiOcak 2025
Cilt / Sayfa43 · 9943-9952
Scopus ID2-s2.0-85189208904
Özet
The objective of research was to examine the likely anticancer effectiveness of distinct pillar[5] arene derivatives, ws-penta-P[5] and ws-deca-P[5], on breast and lung cancer cell lines in vitro. To achieve this goal, breast cancer (MCF7) cells, lung cancer (A549) cells, healthy cells (HEK293) were utilized. The IC50 dose of ws-penta-P[5] and ws-deca-P[5] was determined using the MTT method. Both treatment (pillar[5] arene applied) and control (pillar[5] arene not applied) groups were established for all three cell lines. Real-time polymerase chain reaction (qPCR) was used to evaluate changes in gene expression following pillar[5] arene treatment. Flow cytometry analysis was used to determine apoptosis and cell cycle arrest. The treatment group and control group results were compared after the study. The results revealed that in both cell lines treated with ws-deca-P[5], proapoptotic gene expressions were upregulated, while antiapoptotic gene expressions and caspase activation gene expressions were down-regulated. The flow cytometry apoptosis and cell cycle analysis in treatment group compared to the control, it was observed that the apoptosis rate increased in the ws-deca-P[5] and ws-deca-P[5] were shown to cause G0/G1 phase arrest in both cell groups. Results from our study that pillar[5] arene derivatives had the potential for treating breast and lung cancer, and more research is required in this area. Communicated by Ramaswamy H. Sarma.
Yazarlar (5)
1
Tugce Duran
ORCID: 0000-0002-7353-4527
2
Mehmet Ali Karaselek
3
Serkan Kuccukturk
4
Ahmed Nuri Kursunlu
5
Mustafa Ozmen
ORCID: 0000-0001-5117-9168
Anahtar Kelimeler
apoptosis
breast cancer
Lung cancer
Pillar[5]arene
Kurumlar
Karamanoğlu Mehmetbey Üniversitesi
Karaman Turkey
Karatay Üniversitesi
Konya Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Biomolecular Structure and Dynamics
Q2
SJR Skoru0,533
H-Index98
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Medicine (miscellaneous) (Q2)
Molecular Biology (Q3)
Structural Biology (Q3)
Metrikler
4
Atıf
5
Yazar
4
Anahtar Kelime