Scopus
YÖKSİS Eşleşti
Preparation of graphene-based nanocomposites with spinel ferrite nanoparticles: Their cytotoxic levels in different human cell lines and molecular docking studies
Journal of Organometallic Chemistry · Mayıs 2023
YÖKSİS Kayıtları
Preparation of graphene-based nanocomposites with spinel ferrite nanoparticles: Their cytotoxic levels in different human cell lines and molecular docking studies
Journal of Organometallic Chemistry · 2023 SCI-Expanded
PROFESÖR MUSTAFA ÖZMEN →
Preparation of graphene-based nanocomposites with spinel ferrite nanoparticles: Their cytotoxic levels in different human cell lines and molecular docking studies
Journal of Organometallic Chemistry · 2023 SCI-Expanded
PROFESÖR SALİH ZEKİ BAŞ →
Makale Bilgileri
DergiJournal of Organometallic Chemistry
Yayın TarihiMayıs 2023
Cilt / Sayfa990
Scopus ID2-s2.0-85149203288
Özet
Nanocomposite-modified structures based on reduced graphene oxide (rGO) are preferred because of their excellent advantages. Here we assessed the comparative interaction of graphene oxide (GO), chemically reduced GO (rGO), copper and nickel spinel ferrite nanoparticles (CuFe2O4 NPs and NiFe2O4 NPs) and their nanocomposites with reduced graphene oxide (rGO[sbnd]CuFe2O4, rGO[sbnd]NiFe2O4 NCs). The synthesized nanomaterials were characterized by X-ray diffraction (XRD) and transmission electron microscope (TEM) analysis. The cytotoxic analysis revealed a nontoxic behavior at concentrations below 50 µg/mL in human fetal lung fibroblast (MRC-5), human hepatocellular carcinoma (HepG2), and human glioblastoma (TG98) cell lines. The IC50 values were found to be lower in rGO than that of GO in MRC-5 and T98G cell lines. 50 µg/mL and higher concentrations of rGO[sbnd]CuFe2O4 NCs displayed more potent cytotoxic effects in MRC-5 and HepG2 cell lines compared with the CuFe2O4 NPs. Cytotoxicity was decreased in HepG2 and T98G cell lines treated with rGO[sbnd]NiFe2O4 NCs compared to NiFe2O4 NPs but increased in MRC-5. According to the molecular docking results, DNA binding modes of all nanomaterials were found to be minor groove recognition, while their DNA binding affinities ranged between -4.78 and -12.89 kcal/mol. Docking results showed that, based on their sharp-edged conformations, GO and rGO, and rGO-MFe2O4 (M: Cu, Ni) composites may be promising shape-selective DNA minor groove binders, with the potential to cause specific DNA damage in cancer cells.
Yazarlar (7)
1
Recep Liman
2
Rahsan Ilikci-Sagkan
3
Erman Salih Istifli
4
Keziban Atacan
5
Serkan Erdemir
ORCID: 0000-0003-0790-0549
6
Salih Zeki Bas
ORCID: 0000-0003-2822-8851
7
Mustafa Ozmen
ORCID: 0000-0001-5117-9168
Anahtar Kelimeler
Cytotoxicity
Graphene
Molecular docking
Nanocomposite
Spinel ferrites
Kurumlar
Çukurova Üniversitesi
Adana Turkey
Sakarya University of Applied Sciences
Serdivan Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Usak University
Usak Turkey
Metrikler
2
Atıf
7
Yazar
5
Anahtar Kelime