Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Effect of Silver-Graphene Oxide-Cobalt Oxide Nanocomposite on Cytotoxic Levels in MRC-5 and HepG2 Cell Lines and Molecular Docking Studies
Journal of Cluster Science · Haziran 2024
YÖKSİS Kayıtları
Effect of Silver-Graphene Oxide-Cobalt Oxide Nanocomposite on Cytotoxic Levels in MRC-5 and HepG2 Cell Lines and Molecular Docking Studies
Journal of Cluster Science · 2024 SCI-Expanded
PROFESÖR MUSTAFA ÖZMEN →
Effect of Silver-Graphene Oxide-Cobalt Oxide Nanocomposite on Cytotoxic Levels in MRC-5 and HepG2 Cell Lines and Molecular Docking Studies
JOURNAL OF CLUSTER SCIENCE · 2024 SCI-Expanded
PROFESÖR SALİH ZEKİ BAŞ →
Makale Bilgileri
DergiJournal of Cluster Science
Yayın TarihiHaziran 2024
Cilt / Sayfa35 · 1481-1491
Scopus ID2-s2.0-85189477075
Erişim🔓 Açık Erişim
Özet
The cytotoxic properties of cobalt oxide (Co3O4) nanoparticles (NPs), in addition to graphene oxide (GO)-Co3O4 and silver (Ag)-GO-Co3O4 nanocomposites (NCs), were evaluated against both human healthy lung fibroblast (MRC-5) and hepatocellular carcinoma (HepG2) cell lines utilizing the XTT assay. The investigation revealed that synthesized Co3O4 NPs and NCs (GO-Co3O4 and Ag-GO-Co3O4) elicited significant cytotoxic responses in MRC-5 and HepG2 cell lines in a concentration-dependent manner. Through molecular docking analyses, it was observed that all fabricated nanomaterials exhibited DNA recognition via minor groove binding, with molecular affinities ranging from − 4.82 to -11.66 kcal/mol. Furthermore, the docking outcomes illustrated that the angular conformations of GO-Co3O4 and Ag-GO-Co3O4 conferred ‘shape-selective’ characteristics as DNA minor groove binders, leading to heightened cytotoxicity, particularly in the HepG2 cell line compared to the normal MRC-5 cell line.
Yazarlar (6)
1
Rahsan Ilikci-Sagkan
2
Erman Salih Istifli
3
Recep Liman
4
Keziban Atacan
5
Salih Zeki Bas
ORCID: 0000-0003-2822-8851
6
Mustafa Ozmen
ORCID: 0000-0001-5117-9168
Anahtar Kelimeler
Cobalt oxide
Cytotoxicity
Graphene
Molecular docking
Nanocomposite
Silver
Kurumlar
Çukurova Üniversitesi
Adana Turkey
Sakarya University of Applied Sciences
Serdivan Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Usak University
Usak Turkey