Scopus
🔓 Açık Erişim
L-proline/cholesterol and diosgenin based thiourea cooperative system for the direct asymmetric aldol reaction in the presence of water
Turkish Journal of Chemistry · Temmuz 2020
Makale Bilgileri
DergiTurkish Journal of Chemistry
Yayın TarihiTemmuz 2020
Cilt / Sayfa44 · 1278-1284
Scopus ID2-s2.0-85096183502
Erişim🔓 Açık Erişim
Özet
A series of cholesterol and based hydrophobic urea and thiourea compounds were synthesized and successfully used as a cocatalyst for L-proline catalyzed aldol reactions in the presence of water. The anticonfigured products were obtained with good yields (up to 94%), high diastereoselectivities (up to 95:5), and high enantiomeric excesses (up to 93% ee). The successful results for catalytic efficiency of L-proline in the presence of water reveal the importance of the hydrophobic nature of cholesterol and diosgenin parts of thiourea on the reactivity and selectivity in the presence of water.
Yazarlar (4)
1
S. Eymur
ORCID: 0000-0003-3346-6010
2
E. Taşcı
3
Arzu Uyanik
4
Mustafa Yilmaz
Anahtar Kelimeler
Aldol
Asymmetric synthesis
Organocatalyst
Proline
Kurumlar
Giresun Üniversitesi
Giresun Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
4
Yazar
4
Anahtar Kelime