Scopus
YÖKSİS Eşleşti
Design and Fabrication of a Novel 'Turn-On' NIR Fluorescent Sensor Based on Triphenylamine-Isophorone for Cysteine Sensing and its Application to Drug Analysis and Bioimaging
IEEE Sensors Journal · Kasım 2022
YÖKSİS Kayıtları
Design and Fabrication of a Novel “Turn-On” NIR Fluorescent Sensor Based on Triphenylamine-Isophorone for Cysteine Sensing and its Application to Drug Analysis and Bioimaging
Institute of Electrical and Electronics Engineers (IEEE) · 2022 SCI-Expanded
PROFESÖR SERKAN ERDEMİR →
Makale Bilgileri
DergiIEEE Sensors Journal
Yayın TarihiKasım 2022
Cilt / Sayfa22 · 20200-20206
Scopus ID2-s2.0-85139399324
Özet
Cysteine is a significant biothiol and plays a crucial role in physiological and clinical diagnosis. In the current research, we report a novel near-infrared (NIR) fluorescence sensor derived from triphenylamine-isophorone conjugate for the detection of cysteine. In the sensing pathway, an NIR fluorescence emitting moiety is released after a fast addition-cyclization of cysteine to the methacrylate group, which acts as an emission quencher. The detection platform demonstrates an excellent linear response to cysteine. It has been determined that the probe displays a fast response time (about 4 min), a low detection limit (12.4 nM), and a high signal-to-noise ratio. Easy and quick practical applications such as visual thin layer chromatography (TLC) plate and cotton swab have been established. Also, the current promising approach is effectively applied for the bio-imaging of cysteine in yeast cells and for drug analysis. Thus, this strategy allows the current probe to sense selectively cysteine over other biothiols in 'turn-on' mode.
Yazarlar (3)
1
Serkan Erdemir
ORCID: 0000-0003-0790-0549
2
Sait Malkondu
3
Mehmet Oguz
Anahtar Kelimeler
Cysteine
isophorone
near-infrared (NIR) fluorescence
sensor
triphenylamine
Kurumlar
Giresun Üniversitesi
Giresun Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
4
Atıf
3
Yazar
5
Anahtar Kelime