Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
In vitro vasoactive effects of dexmedetomidine on isolated human umbilical arteries
Bratislava Medical Journal · Ocak 2019
YÖKSİS Kayıtları
In vitro vasoactive effects of dexmedetomidine on isolated human umbilical arteries
Bratislava Medical Journal-Bratislavske Lekarske Listy · 2019 SCI-Expanded
PROFESÖR OĞUZHAN ARUN →
In vitro vasoactive effects of dexmedetomidine on isolated human umbilical arteries
Bratisl Med J · 2019 SCI-Expanded
PROFESÖR JALE BENGİ ÇELİK →
In vitro vasoactive effects of dexmedetomidine on isolated human umbilical arteries
Bratislava Medical Journal · 2019 SCI-Expanded
PROFESÖR ÇETİN ÇELİK →
In vitro vasoactive effects of dexmedetomidine on isolated human umbilical arteries
Bratislava Medical Journal-Bratislavske Lekarske Listy · 2019 SCI-Expanded
PROFESÖR BAHAR ÖÇ →
Makale Bilgileri
DergiBratislava Medical Journal
Yayın TarihiOcak 2019
Cilt / Sayfa120 · 40-45
Scopus ID2-s2.0-85060648204
Erişim🔓 Açık Erişim
Özet
OBJECTIVE: We aimed to investigate the vasoactive effects of dexmedetomidine on isolated human umbilical arteries and possible mechanisms involved. METHODS: Human umbilical artery strips were suspended in Krebs-Henseleit solution and dose-response curves were obtained for cumulative dexmedetomidine before and after incubation with different agents; propranolol, atropine, yohimbine, prazosin, indomethacin, verapamil. Effects of calcium on cumulative dexmedetomidineinduced contractions were also studied. RESULTS: Cumulative dexmedetomidine resulted in dose dependent contraction responses. Incubation with propranolol (Emax: 93.3 ± 3.26 %), atropine (Emax: 92.0 ± 6.54 %), or indomethacin (Emax: 94.25 ± 2.62 %), did not attenuate dexmedetomidine-elicited contractions (p > 0.05). There were significant decreases in the contraction responses of cumulative dexmedetomidine with yohimbine (Emax: 12.1 ± 11.9 %), prazosin (Emax: 28.8 ± 4.6 %) and verapamil (Emax: 11.2 ± 13.6 %) (p < 0.05). In Ca +2 free medium contraction responses to cumulative dexmedetomidine was insignificant (Emax: 5.20 ± 3.42 %). Addition of cumulative calcium to the Ca +2 free medium resulted in concentration dependent increase in contractions (Emax: 64.83 ± 37.7 %) (p < 0.05). CONCLUSION: Dexmedetomidine induces vasoconstriction in endothelial-free umbilical arteries via both, α 1 - and α 2 -adrenergic receptors and also extracellular Ca +2 concentrations play a major role. β-adrenergic receptors, muscarinic cholinergic receptors, and inhibition of cyclooxygenase enzyme are not involved in this vasoconstriction.
Yazarlar (9)
1
Oguzhan Arun
ORCID: 0000-0001-6101-1481
2
Sengal Taylan
3
I. Duman
4
Bahar Oc
ORCID: 0000-0002-2253-5191
5
Setenay Arzu Yilmaz
6
Ahmet Tekin
7
Çetin Çelik
ORCID: 0000-0001-6165-5092
8
Hulagu Bariskaner
ORCID: 0000-0001-6600-4635
9
Jale Çelik
Anahtar Kelimeler
Alpha adrenergic receptors
Dexmedetomidine
In vitro
Umbilical cord
Vascular smooth muscle
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
6
Atıf
9
Yazar
5
Anahtar Kelime