Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Nicotinamide n-methyltransferase expression and its association with phospho-akt, p53 expression, and survival in high-grade endometrial cancer
Turkish Journal of Medical Sciences · Ocak 2019
YÖKSİS Kayıtları
Nicotinamide N-methyltransferase Expression and its Association with Phospho-Akt, p53 Expression and Survival in High Grade Endometrial Cancer
TURKISH JOURNAL OF MEDICAL SCIENCES · 2019 SCI-Expanded
PROFESÖR NEVZAT SERDAR UĞRAŞ →
Nicotinamide N-methyltransferase Expression and its Association with Phospho-Akt, p53 Expression and Survival in High Grade Endometrial Cancer
TURKISH JOURNAL OF MEDICAL SCIENCES · 2019 SCI-Expanded
PROFESÖR ÇETİN ÇELİK →
Nicotinamide N-methyltransferase expression and its association with phospho-Akt, p53 expression, and survival in high-grade endometrial cancer
Turkish Journal Of Medical Sciences · 2019 TR DİZİN
PROFESÖR ÇETİN ÇELİK →
Nicotinamide N-methyltransferase expression and its association with phospho-Akt, p53 expression, and survival in high-grade endometrial cancer
Turkish Journal Of Medical Sciences · 2019 TR DİZİN
DOÇENT İSMAİL HARMANKAYA →
Nicotinamide N-methyltransferase expression and its association with phospho-Akt, p53 expression, and survival in high-grade endometrial cancer
Turkish Journal Of Medical Sciences · 2020 SCI-Expanded
PROFESÖR NEVZAT SERDAR UĞRAŞ →
Makale Bilgileri
DergiTurkish Journal of Medical Sciences
Yayın TarihiOcak 2019
Cilt / Sayfa49 · 1547-1554
Scopus ID2-s2.0-85074163044
Erişim🔓 Açık Erişim
Özet
Background/aim: Nicotinamide N-methyltransferase (NNMT) is an enzyme that is overexpressed in malignancies. NNMT expression has not been previously studied in endometrial cancer (EC). Increased phospho-Akt (pAkt) levels in response to NNMT overexpression have been reported in in vitro studies of different cancer types. We assayed NNMT expression in primary and metastatic high-grade EC and investigated the relationship of NNMT with p53, pAkt, and survival. Materials and methods: NNMT, pAkt, and p53 expressions were assayed in 100 tissue samples of benign endometria, primary EC, and metastatic EC by immunohistochemistry. Results: The NNMT immunoreactivity score was significantly higher in primary high-grade EC than benign endometrial tissue (P = 0.001). NNMT expression in metastatic tissue was significantly higher than in primary cancer (P < 0.001). Metastatic stromal NNMT expression was significantly higher than that of the adjacent tumor and stroma adjacent to the primary tumor. p53 expression in the primary tumor showed a significant positive correlation with omental NNMT and pAkt expression. NNMT expression was also correlated with pAkt expression in metastatic tissue. NNMT overexpression in metastatic tissue was associated with decreased survival (P = 0.039). Conclusion: This study suggests that NNMT may promote cancer progression and that NNMT overexpression is associated with aberrant p53 expression, pAkt, and poor survival. NNMT’s role in cancer progression could make it a target of EC therapy.
Yazarlar (4)
1
Serra Akar
ORCID: 0000-0002-0466-140X
2
İsmail Harmankaya
3
Serdar Uğraş
4
Çetin Çelik
ORCID: 0000-0001-6165-5092
Anahtar Kelimeler
Akt
Disease-specific survival
Nicotinamide N-methyltransferase
P53
Type II endometrial cancer
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
13
Atıf
4
Yazar
5
Anahtar Kelime