Scopus
YÖKSİS Eşleşti
Nicotinamide N-Methyltransferase Expression in Cervical Adenocarcinoma and Its Clinical Significance
Indian Journal of Gynecologic Oncology · Eylül 2019
YÖKSİS Kayıtları
Hypomethylation in Cervical Adenocarcinoma
INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY · 2019 ECSI
PROFESÖR NEVZAT SERDAR UĞRAŞ →
Nicotinamide N-Methyltransferase Expression in Cervical Adenocarcinoma and Its Clinical Significance
Indian Journal of Gynecologic Oncology · 2019 Emerging Sources Citation Index
PROFESÖR ÇETİN ÇELİK →
Nicotinamide N-Methyltransferase Expression in Cervical Adenocarcinoma and Its Clinical Significance
Indian Journal of Gynecologic Oncology · 2019 CNKI Dimensions EBSCO Discovery Service EMBASE Emerging Sources Citation Index Google Scholar INIS Atomindex Institute of Scientific and Technical Information of China Japanese Science and Technology Agency (JST) Naver OCLC WorldCat Discovery Service ProQuest-ExLibris Primo ProQuest-ExLibris Summon SCImago SCOPUS Semantic Scholar TD Net Discovery Service UGC-CARE List (India)
PROFESÖR ÇETİN ÇELİK →
Hypomethylation in Cervical Adenocarcinoma
INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY · 2019 ECSI
PROFESÖR ÇETİN ÇELİK →
Nicotinamide N-Methyltransferase Expression in Cervical Adenocarcinoma and Its Clinical Significance
Indian Journal of Gynecologic Oncology · 2019 CNKI Dimensions EBSCO Discovery Service EMBASE Emerging Sources Citation Index Google Scholar INIS Atomindex Institute of Scientific and Technical Information of China Japanese Science and Technology Agency (JST) Naver OCLC WorldCat Discovery Service ProQuest-ExLibris Primo ProQuest-ExLibris Summon SCImago SCOPUS Semantic Scholar TD Net Discovery Service UGC-CARE List (India)
DOÇENT ERSİN ÇİNTESUN →
Nicotinamide N-Methyltransferase Expression in Cervical Adenocarcinoma and Its Clinical Significance
Indian Journal of Gynecologic Oncology · 2019 Emerging Sources Citation Index
DOÇENT ERSİN ÇİNTESUN →
Nicotinamide N-Methyltransferase Expression in Cervical Adenocarcinoma and Its Clinical Significance
Indian Journal of Gynecologic Oncology · 2019 Emerging Sources Citation Index
DOÇENT İSMAİL HARMANKAYA →
Nicotinamide N-Methyltransferase Expression in Cervical Adenocarcinoma and Its Clinical Significance
INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY · 2019 ESCI
DOÇENT İSMAİL HARMANKAYA →
Makale Bilgileri
DergiIndian Journal of Gynecologic Oncology
Yayın TarihiEylül 2019
Cilt / Sayfa17
Scopus ID2-s2.0-85069692001
Özet
Introduction: Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme increasingly implicated in tumor progression and resistance to treatment. It is overexpressed in human cancers including glioblastoma, gastric, pancreatic, lung and colorectal cancers. The role of NNMT in cervical adenocarcinoma has not been studied thus far. We aimed to evaluate expression of NNMT in cervical adenocarcinoma and investigate its prognostic significance. Methods: NNMT expression was assayed in 18 cases of cervical adenocarcinoma and 19 cases of benign cervical tissue. NNMT immunoreactivity was scored by multiplying staining intensity with percentage of immunoreactive cells. Results: The expression of NNMT was significantly higher in cervical adenocarcinoma than in benign tissue (p = 0.024). NNMT expression was significantly higher in patients with locally advanced than early cervical cancer (p = 0.031). NNMT expression was higher in patients with tumor size greater than 4 cm and in those with poorly differentiated tumors compared to patients with tumors of 4 cm or less and well-moderate differentiation, respectively (p = 0.044, p = 0.014). Conclusion: Although on a preliminary level, this is the first study to detect an overexpression of NNMT in cervical adenocarcinoma and an increased expression associated with advanced stage, increased tumor size and poor differentiation. NNMT has been shown to carry prognostic and therapeutic importance in a variety of cancers, and it can be a potential treatment target in cervical adenocarcinomas.
Yazarlar (5)
1
Serra Akar
ORCID: 0000-0002-0466-140X
2
İsmail Harmankaya
3
Serdar Uğraş
4
Ersin Çintesun
ORCID: 0000-0001-8507-5850
5
Çetin Çelik
ORCID: 0000-0001-6165-5092
Anahtar Kelimeler
Cervical adenocarcinoma
Nicotinamide N-methyltransferase
Stage
Tumor grade
Tumor size
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey