Scopus
YÖKSİS Eşleşti
Nicotinamide N-Methyltransferase Expression in High-Grade Serous Carcinoma and Its Association with Survival
Indian Journal of Gynecologic Oncology · Aralık 2019
YÖKSİS Kayıtları
Nicotinamide N-Methyltransferase Expression in High-Grade Serous Carcinoma and Its Association with Survival
Indian Journal of Gynecologic Oncology · 2019 Emerging Sources Citation Index
PROFESÖR ÇETİN ÇELİK →
Methyltransferase in High-Grade Serous Carcinoma
INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY · 2019 ESCI: Emerging Sources Citation Index
PROFESÖR ÇETİN ÇELİK →
Nicotinamide N-Methyltransferase Expression in High-Grade Serous Carcinoma and Its Association with Survival
Indian Journal of Gynecologic Oncology · 2019 Emerging Sources Citation Index
DOÇENT İSMAİL HARMANKAYA →
Nicotinamide N-Methyltransferase Expression in High-Grade Serous Carcinoma and Its Association with Survival
INDIAN JOURNAL OF GYNECOLOGIC ONCOLOGY · 2019 ESCI
DOÇENT İSMAİL HARMANKAYA →
Nicotinamide N-Methyltransferase Expression in High-Grade Serous Carcinoma and Its Association with Survival
Indian Journal of Gynecologic Oncology · 2019 Emerging Sources Citation Index
PROFESÖR NEVZAT SERDAR UĞRAŞ →
Makale Bilgileri
DergiIndian Journal of Gynecologic Oncology
Yayın TarihiAralık 2019
Cilt / Sayfa17
Scopus ID2-s2.0-85073073014
Özet
Introduction: Ovarian cancer is the most lethal gynecological malignancy. Mechanisms involved in the progression of primary high-grade serous carcinoma (HGSC) into metastatic carcinoma are not understood. Nicotinamide N-methyltransferase (NNMT) is overexpressed in cancer, and its overexpression leads to epigenetic changes through hypomethylation of histones. It plays a role in epithelial–mesenchymal transition and sustenance of cancer stem cells. NNMT expression in primary and metastases of ovarian carcinoma and its relationship with survival have not been studied before. Materials and Methods: We compared the expression of NNMT between primary and matched synchronous metastatic carcinoma of patients, diagnosed with HGSC. Benign ovarian and omental tissues were used as controls. The relationships between NNMT expression and relapse-free and disease-specific survival were analyzed. Results: NNMT expression in metastases was significantly higher than matched primary carcinoma. NNMT was overexpressed in the stroma of primary and metastatic tumors. Increased NNMT expression was associated with decreased relapse-free and disease-specific survival. Conclusion: This study detected a higher expression of NNMT in metastases of HGSC compared to matched primary and associated increased metastatic NNMT expression with decreased survival. Upregulation of NNMT in tumor stroma suggests it plays a role in desmoplasia. Targeting of NNMT and desmoplasia may play a critical role in the treatment of HGSC.
Yazarlar (4)
1
Serra Akar
ORCID: 0000-0002-0466-140X
2
İsmail Harmankaya
3
Serdar Uğraş
4
Çetin Çelik
ORCID: 0000-0001-6165-5092
Anahtar Kelimeler
Disease-specific survival
High-grade serous carcinoma
Nicotinamide N-methyltransferase
p53
Relapse-free survival
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
4
Yazar
5
Anahtar Kelime