Scopus
YÖKSİS Eşleşti
A Sensitive Amperometric Biosensor Based on Carbon Dot 3-Chloropropyl-trimethoxysilane Modified Electrode for Detection of Neurotransmitter Dopamine
Journal of the Electrochemical Society · Mart 2023
YÖKSİS Kayıtları
A Sensitive Amperometric Biosensor Based on Carbon Dot 3-Chloropropyl-trimethoxysilane Modified Electrode for Detection of Neurotransmitter Dopamine
The Electrochemical Society · 2023 SCI-Expanded
DOÇENT SALİHA DİNÇ →
A sensitive amperometric biosensor based on carbon dot 3-chloropropyl-trimethoxysilane modified electrode for detection of neurotransmitter dopamine
Journal of The Electrochemical Society · 2023 SCI-Expanded
PROFESÖR MUSTAFA ÖZMEN →
A Sensitive Amperometric Biosensor Based on Carbon Dot 3-Chloropropyl-trimethoxysilane Modified Electrode for Detection of Neurotransmitter Dopamine
The Electrochemical Society · 2023 SCI-Expanded
PROFESÖR MERYEM KARA →
Makale Bilgileri
DergiJournal of the Electrochemical Society
Yayın TarihiMart 2023
Cilt / Sayfa170
Scopus ID2-s2.0-85150775551
Özet
Dopamine (DA) is an important electroactive neurotransmitter. The concentration of DA in the body of a healthy person is approximately 1.0 × 10−7−1.0 × 10−3 M. A decrease in dopamine concentration is associated with Parkinson’s disease. Thus, it is important to determine the amount of dopamine in early diagnosis of Parkinson’s disease. Different methods such as immunoassay, flow injection analysis (FIA), high performance liquid chromatography (HPLC) etc could be used for determination of dopamine but they are expensive and have long determination times, and pre analytic processes. In this study, a tyrosinase based amperometric biosensor was developed with carbon paste electrode modified with carbon nano dot 3-Chloropropyl-trimethoxysilane (CDs-CPTMS) for determination of the amount of dopamine. CDs-CPTMS was synthesized for the first time. Determination of dopamine was carried out by the reduction of dopamine-o-quinone at −0.15 V versus Ag/AgCl. The effect of temperature, pH, and substrate concentration on the dopamine response of the prepared biosensor and interference effect were investigated. There was no interference effect of uric acid and ascorbic acid. The designed biosensor has wide working range (0.001-0.01 μM and 0.01−0.1 μM), low limit of detection, very good reproducibility and shelf life. In addition, the preparation of the biosensor is practical and cost-effective.
Yazarlar (8)
1
Muhammed Ali Akbıyık
2
Onur Can Bodur
3
Merve Keskin
ORCID: 0000-0001-9365-334X
4
Meryem Kara
5
Saliha Dinç
6
Halit Arslan
7
Mustafa Ozmen
ORCID: 0000-0001-5117-9168
8
Fatma Arslan
Kurumlar
Bilecik Şeyh Edebali Üniversitesi
Bilecik Turkey
Gazi Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
9
Atıf
8
Yazar