Scopus
YÖKSİS Eşleşti
Serum sRAGE and sE-selectin levels are useful biomarkers of lung injury and prediction of mortality in calves with perinatal asphyxia
Theriogenology · Mart 2022
YÖKSİS Kayıtları
Serum sRAGE and sE-selectin levels are useful biomarkers of lung injury and prediction of mortality in calves with perinatal asphyxia
Theriogenology · 2022 SCI-Expanded
DOÇENT MERVE İDER →
Serum sRAGE and sE-selectin levels are useful biomarkers of lung injury and prediction of mortality in calves with perinatal asphyxia
Theriogenology · 2022 SCI
PROFESÖR KAMİL ÜNEY →
Serum sRAGE and sE-selectin levels are useful biomarkers of lung injury and prediction of mortality in calves with perinatal asphyxia
Theriogenology · 2022 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ TUĞBA MELİKE PARLAK →
Makale Bilgileri
DergiTheriogenology
Yayın TarihiMart 2022
Cilt / Sayfa181 · 113-118
Scopus ID2-s2.0-85123248468
Özet
The objective of the present study was to evaluate the biomarkers specific to lung endothelial and epithelial damage in the determination of lung injury and its severity in calves with perinatal asphyxia and to evaluate their prognostic importance among survivors and non-survivor calves. Ten healthy calves and 20 calves with perinatal asphyxia were enrolled in the study. Clinical examination and laboratory analysis were performed at admission. Serum concentrations of soluble advanced glycation end-product receptor (sRAGE), soluble E-selectin (sE-selectin), clara cell secretory protein (CC16), and soluble intercellular adhesion molecule-1 (sICAM-1) were measured to assess lung injury. Venous pH, sO2, HCO3, and BE of calves with perinatal asphyxia were significantly lower than the healthy calves. sRAGE, sE-selectin, pCO2, and lactate were significantly high in calves with asphyxia. ROC analysis showed that sRAGE, sE-selectin, pCO2, lactate, and respiratory rate were higher while HCO3 and BE were lower in the nonsurvivor calves than survivors. In conclusion, serum sRAGE and sE-selectin concentrations highlight the utility of these biomarkers in determining lung injury in calves with asphyxia. Also, pH, pCO2, lactate, HCO3, BE, and respiratory rate along with serum sRAGE and sE-selectin were useful indicators in the prediction of mortality.
Yazarlar (8)
1
Merve Ider
ORCID: 0000-0003-2928-5452
2
Amir Naseri
3
M. Ok
4
Erdem Gülersoy
ORCID: 0000-0001-8511-0150
5
T. M. Bas
6
Kamil Üney
ORCID: 0000-0002-8674-4873
7
T. M. Parlak
8
A. Abdelaziz
Anahtar Kelimeler
Biomarker
Calf
Lung
Perinatal asphyxia
Respiratory distress syndrome
Kurumlar
Harran Üniversitesi
Sanliurfa Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
10
Atıf
8
Yazar
5
Anahtar Kelime