Scopus
YÖKSİS Eşleşti
Histopathological and biochemical evaluation of the protective efficacy of Prunus spinosa L. extract in a rat model of indomethacin-induced gastric ulcer
Iranian Journal of Basic Medical Sciences · Kasım 2024
YÖKSİS Kayıtları
Histopathological and biochemical evaluation of the protective efficacy of Prunus spinosa L. extract in a rat model of indomethacin-induced gastric ulcer
Iranian Journal of Basic Medical Sciences · 2024 SCI-Expanded
PROFESÖR OSMAN TUGAY →
Histopathological and biochemical evaluation of the protective efficacy of Prunus spinosa L. extract in a rat model of indomethacin-induced gastric ulcer
Iranian Journal of Basic Medical Sciences · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ NERİMAN AKDAM →
Histopathological and biochemical evaluation of the protective efficacy of Prunus spinosa L. extract in a rat model of indomethacin-induced gastric ulcer
Iranian Journal of Basic Medical Sciences · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MELTEM GÜMÜŞ →
Histopathological and biochemical evaluation of the protective efficacy of Prunus spinosa L. extract in a rat model of indomethacin-induced gastric ulcer
Iranian Journal of Basic Medical Sciences · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ CENGİZHAN CEYLAN →
Histopathological and biochemical evaluation of the protective efficacy of Prunus spinosa L. extract in a rat model of indomethacin-induced gastric ulcer
IRANIAN JOURNAL OF BASIC MEDİCAL SCIENCES · 2024 SCI-Expanded
PROFESÖR ZELİHA ESİN ÇELİK →
Histopathological and biochemical evaluation of the protective efficacy of Prunus spinosa L. extract in a rat model of indomethacin-induced gastric ulcer
Iranian Journal of Basic Medical Sciences · 2024 SCI-Expanded
PROFESÖR NİHAL ÇETİN →
Histopathological and biochemical evaluation of the protective efficacy of Prunus spinosa L. extract in a rat model of indomethacin-induced gastric ulcer
Iranian Journal of Basic Medical Sciences · 2024 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ TUĞSEN BÜYÜKYILDIRIM →
Histopathological and biochemical evaluation of the protective efficacy of Prunus spinosa L. extract in a rat model of indomethacin-induced gastric ulcer
Iranian Journal of Basic Medical Sciences · 2024 SCI-Expanded
PROFESÖR ESMA MENEVŞE →
Histopathological and biochemical evaluation of the protective efficacy of Prunus spinosa L. extract in a rat model of indomethacin-induced gastric ulcer
Iranian Journal of Basic Medical Sciences · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ ŞEYMA TETİK RAMA →
Makale Bilgileri
DergiIranian Journal of Basic Medical Sciences
Yayın TarihiKasım 2024
Cilt / Sayfa27 · 1464-1474
Scopus ID2-s2.0-85204072508
Özet
Objective(s): Some species of Prunus L. are popularly used to treat gastric ulcers. However, the possible healing mechanisms of the anti-ulcer activity of P. spinosa, which has proven antioxidant, anti-inflammatory, and wound-healing properties, are unclear. Materials and Methods: Ethanol extracts of P. spinosa fruits were administered orally at 100 mg/ kg and 200 mg/kg to Wistar albino rats, with an indomethacin-induced gastric ulcer model. The ulcerous areas on the stomach surface were examined macroscopically. Tissues were examined histopathologically and biochemically. LC-HRMS revealed the phytochemical content. Results: TNF-α, IL-6, IL-1β, IL-8, and NF-kB levels were higher in the gastric ulcer group than in the extract groups. The VEGF values did not differ in each group. A significant difference was found between the lansoprazole group and the high-dose P. spinosa group regarding PGE2 levels. A histopathologically significant difference was observed between the healthy group and the indomethacin-applied groups in terms of neutrophilic infiltration of the gastric mucosa. Ascorbic acid (1547.521 µg/g), homoprotocatechuic acid (1268.217 µg/g), and genistein (1014.462 µg/g) were found as the main compounds in the P. spinosa extract by LC-HRMS. Conclusion: Our results demonstrated that P. spinosa protected the gastric mucosa from inflammation and also modulated the PGE2 pathway. When considered in terms of TNF-α, IL-1β, IL-8, IL-6, PGE2, and NF-kB values, it can be concluded that it has a similar or even more positive effect than the reference substance. P. spinosa showed its effects in a dose-dependent manner.
Yazarlar (10)
1
Nihal Cetin
2
Esma Menevşe
3
Cengizhan Ceylan
ORCID: 0000-0003-4164-9212
4
Zeliha Esin Celik
5
Neriman Akdam
6
Seyma Tetik Rama
7
Tugsen Buyukyildirim
8
Leyla Paşayeva
ORCID: 0000-0003-3860-7222
9
Osman Tugay
10
Meltem Gumus
Anahtar Kelimeler
Gastric ulcer
LC-HRMS
PGE2
Prunus spinosa
TNF-α
Kurumlar
Erciyes Üniversitesi
Kayseri Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey