Scopus
YÖKSİS Eşleşti
The effects of bisphenol A on some plasma cytokine levels and distribution of CD8<sup>+</sup> and CD4<sup>+</sup> T lymphocytes in spleen, ileal Peyer's patch and bronchus associated lymphoid tissue in rats
Acta Histochemica · Kasım 2018
YÖKSİS Kayıtları
The effects of bisphenol A on some plasma cytokine levels and distribution of CD8(+) and CD4(+) T lymphocytes in spleen, ileal Peyer's patch and bronchus associated lymphoid tissue in rats
ACTA HISTOCHEMICA · 2018 SCI
PROFESÖR İLHAMİ ÇELİK →
Makale Bilgileri
DergiActa Histochemica
Yayın TarihiKasım 2018
Cilt / Sayfa120 · 728-733
Scopus ID2-s2.0-85051379680
Özet
The effects of bisphenol A on the some plasma cytokine levels and distribution of CD8+ and CD4+ T lymphocytes in spleen, ilealPeyer's patch and bronchus-associated lymphoid tissue in rats were investigated. A total of fourty male Wistar Albino rats were divided into five groups including 8 rats in each one: control, vehicle, BPA 5, BPA 50 and BPA 500 groups. Doses of 5, 50 and 500 μg/kg BPA were dissolved in ethanol, then mixed with corn oil. The control group received no treatment. The vehicle group was given the ethanol-corn oil mixture. BPA 5, BPA 50 and BPA 500 groups were given, respectively, 5, 50, and 500 μg/kg/day orally. In blood samples, IL-4, IL-6, IL-10 and TNF-α plasma levels were determined with ELISA. Tissue samples (spleen, ileal Peyer's patches and lung) were processed by means of routine histological techniques. CD4 and CD8 were stained immunohistochemically. Data obtained from this study showed that, BPA causes the alteration on immune parameters including cytokine profile, distribution of CD8+ and CD4+ T lymhpocytes in spleen and ileal Peyer's patches. Present study indicated that BPA may affect immune systems even at lower doses.Disruption of immun system cells and cytokine levels can result in harmful outcomes triggering autoimmune diseases and immunodeficiencies.
Yazarlar (5)
1
Tuǧba Özaydin
2
Yasemin Öznurlu
3
Emrah Sur
4
Ilhami Çelik
5
Deniz Uluíşik
Anahtar Kelimeler
Bisphenol A
Bronchus-associated lymphoid tissue
Cytokines
Ileal Peyer's patches
Immunohistochemistry
Spleen
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
18
Atıf
5
Yazar
6
Anahtar Kelime