Scopus
YÖKSİS Eşleşti
Melatonin prevents oxidant damage in various tissues of rats with hyperthyroidism
Life Sciences · Haziran 2006
YÖKSİS Kayıtları
Melatonin prevents oxidant damage in various tissues of rats with hyperthyroidism
Life Sciences · 2006 SCI
PROFESÖR ABDULLAH SİVRİKAYA →
Melatonin prevents oxidant damage in various tissues of rats with hyperthyroidism
Life Sciences · 2006 SCI-Expanded
PROFESÖR ABDULLAH SİVRİKAYA →
Makale Bilgileri
DergiLife Sciences
Yayın TarihiHaziran 2006
Cilt / Sayfa79 · 311-315
Scopus ID2-s2.0-33646858116
Özet
Impairment of thyroid functions brings about pathological changes in different organs of body. Findings of in vivo and in vitro studies indicate that thyroid hormones have a considerable impact on oxidative stress. Melatonin reduces oxidative damage through its free radical eliminating and direct anti-oxidant effects. The present study was undertaken to determine how a 3-week period of intraperitoneal melatonin administration affected oxidative damage caused in experimental hyperthyroidism in rat. The experimental animals were divided into 3 groups (control, hyperthyroidism, hyperthyroidism + melatonin). Malondialdehyde (MDA) and glutathione (GSH) levels were determined in different tissues. MDA levels in cerebral, liver and cardiac tissues in hyperthyroidism group were significantly higher than those in control and hyperthyroidism + melatonin supplemented groups (p < 0.001). The highest GSH levels were observed in the group that was administered melatonin in addition to having hyperthyroidism (p < 0.001). These results show that hyperthyroidism increased oxidative damage in cerebral, hepatic and cardiac tissues of rat. Melatonin supplementation may also suppress oxidative damage. © 2006 Elsevier Inc. All rights reserved.
Yazarlar (5)
1
Rasim Mogulkoc
2
Abdulkerim Kasim Baltaci
3
E. Oztekin
4
Leyla Aydin
5
Abdullah Sivrikaya
Anahtar Kelimeler
Hyperthyroidism
Melatonin administration
Oxidant damage
Rat
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
40
Atıf
5
Yazar
4
Anahtar Kelime