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Kynurenine pathway of tryptophan metabolism in patients with familial Mediterranean fever

Modern Rheumatology · Mart 2023

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YÖKSİS Kayıtları
Kynurenine pathway of tryptophan metabolism in patients with familial Mediterranean fever
Modern Rheumatology · 2022 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Kynurenine pathway of tryptophan metabolism in patients with familial Mediterranean fever
Modern Rheumatology · 2022 SCI-Expanded
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
Kynurenine pathway of tryptophan metabolism in patients with familial Mediterranean fever
MODERN RHEUMATOLOGY · 2023 SCI
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 10 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
P wave duration and dispersion in children with uncomplicated familial Mediterranean fever
2013 ISSN: 1439-7595 SCI-Expanded 3 atıf
Prof. Dr. HÜSAMETTİN VATANSEV →
P-wave duration and dispersion in children with uncomplicated familial Mediterranean fever
2013 ISSN: 1439-7595 SCI-Expanded
Prof. Dr. HARUN PERU →
P-wave duration and dispersion in children with uncomplicated familial Mediterranean fever
2013 ISSN: 1439-7595 SCI
Prof. Dr. HÜSAMETTİN VATANSEV →
The effect of gender on disease activity and clinical characteristics in patients with axial psoriatic arthritis
2020 ISSN: 1439-7595 SCI-Expanded
Prof. Dr. İLKNUR ALBAYRAK GEZER →
Antiphospholipid antibodies in COVID-19-associated pneumonia patients in intensive care unit
2021 ISSN: 1439-7595 SCI-Expanded Q4
Doç. Dr. KEMAL EROL →
Kynurenine pathway of tryptophan metabolism in patients with familial Mediterranean fever
2023 ISSN: 1439-7595 SCI-Expanded Q3
Prof. Dr. ABDULLAH SİVRİKAYA →
Kynurenine pathway of tryptophan metabolism in patients with familial Mediterranean fever
2022 ISSN: 1439-7595 SCI-Expanded Q3
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
What is the impact of methotrexate on liver in patients with juvenile idiopathic arthritis? Results of liver SWE performed in a single centre
2022 ISSN: 1439-7595 SCI-Expanded Q2
Prof. Dr. MEHMET ÖZTÜRK →
Does Obesity Affect Treatment Response to Secukinumab and Its Survival in Ankylosing Spondylitis? Real-life Data from the TURKBIO Registry
2024 ISSN: 1439-7595 SCI-Expanded Q4
Prof. Dr. SEMA YILMAZ →
Kynurenine pathway of tryptophan metabolism in patients with familial Mediterranean fever
2023 ISSN: 1439-7595 SCI Q4
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →

Makale Bilgileri

Dergi Modern Rheumatology
ISSN14397595
Yayın TarihiMart 2023
Cilt / Sayfa33 · 398-407
DOI10.1093/mr/roac016
Scopus ID2-s2.0-85137964223
Özet Background: Familial Mediterranean fever (FMF) is an autoinflammatory syndrome characterized by recurrent episodes of fever and aseptic polyserositis. Subclinical inflammation generates a hidden threat to the development of FMF complications such as amyloidosis in attack-free intervals. The kynurenine pathway (KP) has been considered an important player in inflammation and immune response. The study was aimed to measure serum levels of KP metabolites in patients with FMF in the attack-free period. Methods: A total of 161 participants were recruited from the rheumatology department in this single-centre, case–control study. Participants meeting the eligibility criteria were divided into healthy controls (n = 80) and FMF (n = 81). The laboratory data were obtained from the electronic registration database. Serum tryptophan (TRP), kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxyanthranilic acid, 3-hydroxykynurenine (3HK), and quinolinic acid (QUIN) concentrations were measured with tandem mass spectrometry. Laboratory findings of FMF patients and healthy controls subjects were compared and evaluated. Results: Serum TRP and KYNA levels were significantly decreased in both FMF groups compared to the control group, while the levels of KYN, QUIN, 3HK, the KYN/TRP ratio, and red cell distribution width were higher. Conclusion: TRP degradation by the KP is increased in patients with FMF. KP metabolites can be useful in demonstrating subclinical inflammation.

Yazarlar (7)

1
Dilek Tezcan
ORCID: 0000-0002-8295-9770
2
Duygu Eryavuz Onmaz
ORCID: 0000-0001-8564-1824
3
Abdullah Sivrikaya
4
M. K. Korez
ORCID: 0000-0001-9524-6115
5
Selda Hakbilen
ORCID: 0000-0002-6417-7310
6
Semral Gülcemal
ORCID: 0000-0002-6085-9939
7
Sema Yılmaz
ORCID: 0000-0003-4277-3880

Anahtar Kelimeler

Familial Mediterranean fever inflammation kynurenine pathway tryptophan

Kurumlar

Selçuk Tip Fakültesi
Konya Turkey
University of Health Sciences
Istanbul Turkey
Scimago Dergi (ISSN Eşleşmesi)
Modern Rheumatology
Q2
SJR Skoru0,765
H-Index74
YayıncıOxford University Press
ÜlkeUnited Kingdom
Medicine (miscellaneous) (Q2)
Rheumatology (Q2)
Dergi sayfasına git

Metrikler

7
Atıf
7
Yazar
4
Anahtar Kelime

Sistemimizdeki Yazarlar

AS
ABDULLAH SİVRİKAYA
Prof. Dr.

Hızlı Erişim

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