Scopus
YÖKSİS Eşleşti
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
Journal of Drug Delivery Science and Technology · Kasım 2024
YÖKSİS Kayıtları
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY · 2024 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ KÜBRA YILMAZ →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
Journal of Drug Delivery Science and Technology · 2024 SCI-Expanded
ÖĞRETİM GÖREVLİSİ FATİH ÖZCAN →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
Journal of Drug Delivery Science and Technology · 2024 SCI-Expanded
PROFESÖR ABDULLAH SİVRİKAYA →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
Journal of Drug Delivery Science and Technology · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ ŞEYMA TETİK RAMA →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
Journal of Drug Delivery Science and Technology · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ CENGİZHAN CEYLAN →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
Journal of Drug Delivery Science and Technology · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ HARUN YONAR →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
Journal of Drug Delivery Science and Technology · 2024 SCI-Expanded
PROFESÖR ESRA MALTAŞ ÇAĞIL →
Makale Bilgileri
DergiJournal of Drug Delivery Science and Technology
Yayın TarihiKasım 2024
Cilt / Sayfa101
Scopus ID2-s2.0-85206260390
Özet
Burn treatments with gene therapy and healing factors requires highly cost techniques. Instead, topical formulations including plant extract or pharmaceuticals are offered for wound-healing effect. However, these have low water solubility and cannot uptake into cells sufficiently. To overcome disadvantages, new effective treatment approaches should have been accessible. This study aimed to develop nanofiber-based wound coverings using four different Ag(I)-calixarene derivatives. Their nanofibers were produced by the electrospin method, and evaluated in vivo in rats with a second-degree burn model. Biochemical analysis has been maintained to exmine the effects of formulations on such as growth factors and some cytokines that are effective in wound healing process. In addition, histopathological analyzes has been performed to evaluate the presence and density of granulation tissue, inflammation, epithelial thickness and fibrosis. All data were compared with a commercial topical, silver sulfadiazine, whose usage is limited due to various disadvantages in the treatment processes of burn wounds. In this study, four different calixarene derivatives were synthesized their nanofibers were produced by the electrospin method, and their effectiveness was evaluated in vivo in rats with a second-degree burn model. Then, various biochemical and histopathological analyses were done to elucidate the possible wound-healing mechanism. When considering both pathological and biochemical data, the nanofibers of CLX-SAMD-Ag (5,11,17,23‐tetra‐tert‐butyl‐25,27‐bis(Sulfadiazine)‐26,28‐propylcalix (Xie and Unser, 2013) [4]arene - Ag) and CLX-MORF- Ag (5,11,17,23‐tetra‐tert‐butyl‐25,27‐bis(3-Morpholinopropil)‐26,28‐dihydroxycalix (Xie and Unser, 2013) [4]arene-Ag) were found to be more effective than silver sulfadiazine -silver content application, also known as traditional burn treatment for wound healing.
Yazarlar (8)
1
Esra Maltas Cagil
ORCID: 0000-0001-7574-6016
2
Fatih Ozcan
3
Cengizhan Ceylan
ORCID: 0000-0003-4164-9212
4
Seyma Tetik Rama
5
Kubra Yilmaz
6
Zeliha Esin Celik
7
Abdullah Sivrikaya
8
Harun Yonar
Anahtar Kelimeler
Calixarene
Healing
Inflammation
Nanofiber
Rat
Wound
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey