Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Hepatoprotective effects of Nigella Sativa oil against acrylamide-induced liver injury in rats
Ankara Universitesi Veteriner Fakultesi Dergisi · Ocak 2023
YÖKSİS Kayıtları
Hepatoprotective Effects of Nigella Sativa Oil against Acrylamide-induced Liver Injury in Rats
Ankara Üniversitesi Veteriner Fakültesi Dergisi · 2023 SCI-Expanded
Prof. Dr. HASAN HÜSEYİN DÖNMEZ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Serum ceruloplasmin and paraoxonase-1 levels in ovariectomized and ovariohysterectomized dogs
2015 ISSN: 1300-0861 SCI-Expanded
Doç. Dr. KÜBRA KARAKAŞ ALKAN →
The role of different trehalose concentrations and cooling rates in freezing of ram semen
2009 ISSN: 1300-0861 SCI-Expanded 5 atıf
Prof. Dr. MUSTAFA NUMAN BUCAK →
Effects of dietary sepiolite on performance egg quality and some blood parameters in laying hens
2016 ISSN: 1300-0861 SCI-Expanded
Prof. Dr. SUZAN YALÇIN →
Effects of brooder machine rearing method in the first week on fattening performance, carcass characteristics, meat quality and some blood parameters of Pekin ducks
2015 ISSN: 1300-0861 SCI-Expanded
Prof. Dr. SUZAN YALÇIN →
The Determination of Situation and Breed Charecteristics of Turkish Rahvan Horse in Turkey
2010 ISSN: 1300-0861 SCI-Expanded
Prof. Dr. AYTEKİN GÜNLÜ →
Financial losses due to lameness in dairy herds in Burdur, Kirklareli and Konya Provinces Turkey
2010 ISSN: 1300-0861 SCI
Prof. Dr. AYTEKİN GÜNLÜ →
A Comparison of Egg Quality Characteristics of Partridge and Pheasant Eggs P colchicus A graeca
2010 ISSN: 1300-0861 SSCI
Prof. Dr. AYTEKİN GÜNLÜ →
Effects of dietary yeast cell wall on performance egg quality and humoral immune response in laying hens
2014 ISSN: 1300-0861 SCI-Expanded
Prof. Dr. SUZAN YALÇIN →
Effects of hypothyroidism and hyperthyroidism on hematological parameters in rats
2016 ISSN: 1300-0861 SCI-Expanded
Prof. Dr. ERCAN KESKİN →
Kuru döneme çıkarken enfekte ve sağlıklı meme loblarında California Mastitis Test ve somatik hücre sayısı ile bakteriyolojik muayene sonuçlarının karşılaştırılması
2014 ISSN: 1300-0861 SCI-Expanded
Doç. Dr. HASAN ALKAN →
Serum ceruloplasmin and paraoxonase-1 levels in ovariectomized and ovariohysterectomized dogs
2015 ISSN: 1300-0861 SCI-Expanded
Doç. Dr. HASAN ALKAN →
Investigation of mycotoxin residues in poultry feeds by LC MS/MS method
2017 ISSN: 1300-0861 SCI-Expanded
Prof. Dr. HALİS UĞUZ →
Chewing lice (Phthiraptera: Amblycera, Ischnocera) of some aquatic birds in Konya province, Turkey, new records for Turkish fauna
2017 ISSN: 1300-0861 SCI-Expanded
Doç. Dr. ONUR CEYLAN →
The effects of various essential oils Carvacrol Cinnamaldehyde Thymol having antimicrobial properties that are applied to broilerlitter on litter hygiene and broiler performance
2011 ISSN: 1300-0861 SCI
Prof. Dr. İSKENDER YILDIRIM →
LimuzinXJersey melezi ve Holştayn ırkı tosunlarda optimal besi süresinin tespiti üzerine bir araştırma
1996 ISSN: 1300-0861 SCI-Expanded
Prof. Dr. AYTEKİN GÜNLÜ →
Histomorphometric examination of the pineal gland in foals and adult horses
2018 ISSN: 1300-0861 SCI-Expanded
Prof. Dr. SADULLAH BAHAR →
The light microscopic investigation of the effects of in-ovo administered bisphenol A (BPA) on the development of testes
2018 ISSN: 1300-0861 SCI-Expanded
Prof. Dr. EMRAH SUR →
Histomorphometric examination of the pineal gland in foals and adult horses.
2018 ISSN: 1300-0861 SCI-Expanded Q4
Prof. Dr. SADULLAH BAHAR →
Makale Bilgileri
ISSN13000861
Yayın TarihiOcak 2023
Cilt / Sayfa70 · 419-426
Scopus ID2-s2.0-85173010811
Erişim🔓 Açık Erişim
Özet
Acrylamide (AA) is a heat-induced carcinogen founds in some foods due to cooking or other thermal processes. This study was designed to investigate the possible protective efficacy of Nigella sativa essential oil against acrylamide-induced liver toxicity. Four groups of 32 male Wistar albino rats were formed. The control group was fed ad libitum. Acrylamide was administered to the rats in Group AA at a daily dose of 40 mg/kg by gavage. Nigella sativa essential oil was administered intraperitoneally at a dose of 10mg/kg to the rats in Group NS. In Group AA+NS, daily applications of acrylamide and Nigella sativa essential oil were applied simultaneously as mentioned above. The trial period lasted 15 days. While acrylamide statistically increased MDA levels in liver tissue (P<0.05), (146.13 %) and decreased GSH and SOD activity statistically (P<0.05), (55.28% and 40.46%). In addition, liver proinflammatory cytokine levels increased due to acrylamide administration (P<0.05), [TNF-α (78.17%), IL-6 (76.08%)], anti-inflammatory cytokine levels (P<0.05), [IL-10 (61.16%)] decreased. Co-administration of Nigella sativa essential oil with acrylamide significantly reduced oxidative stress and pro-inflammatory cytokine levels in liver tissues (P<0.05). In conclusion, our findings highlighted the potential therapeutic role of Nigella sativa essential oil in preventing acrylamide-induced hepatotoxicity.
Yazarlar (4)
1
Durmus Hatipoglu
ORCID: 0000-0003-3790-7821
2
M. Özsan
3
Hasan Hüseyin Dönmez
4
Nurcan Dönmez
Anahtar Kelimeler
Acrylamide
Cytokines
Hepatotoxicity
Nigella sativa
Oxidative stress
Kurumlar
Bartin Üniversitesi
Bartin Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Ankara Universitesi Veteriner Fakultesi Dergisi
Q3
OA
SJR Skoru0,271
H-Index19
YayıncıAnkara University
ÜlkeTurkey
Animal Science and Zoology (Q3)
Veterinary (miscellaneous) (Q3)
Metrikler
10
Atıf
4
Yazar
5
Anahtar Kelime