Scopus
YÖKSİS Eşleşti
The effect of grape seed extracts on serum paraoxonase activities in streptozotocin-induced diabetic rats
Journal of Medicinal Food · Haziran 2010
YÖKSİS Kayıtları
The Effect of Grape Seed Extracts on Serum Paraoxonase Activities inStreptozotocin Induced Diabetic Rats
JOURNAL OF MEDICINAL FOOD · 2010 SSCI 12 atıf
PROFESÖR NİLSEL OKUDAN →
The Effect of Grape Seed Extracts on Serum Paraoxonase Activities in Streptozotocin Induced Diabetic Rats
Journal of Medicinal Food · 2010 SCI
PROFESÖR MUAZ BELVİRANLI →
Makale Bilgileri
DergiJournal of Medicinal Food
Yayın TarihiHaziran 2010
Cilt / Sayfa13 · 725-728
Scopus ID2-s2.0-77953773615
Özet
Procyanidins, a group of flavonoids, are oligomeric forms of catechins that are abundant in red wine, grapes, cocoa, and apples. Paraoxonase acts as an antioxidant enzyme and protects low-density lipoprotein-cholesterol against oxidation. In our study we aimed to evaluate the effects of grape seed extract (GSE) on paraoxonase activities in streptozotocin-induced diabetic rats. Our study included four groups of rats: Group I (n = 8), control; Group II (n = 10), GSE-supplemented; Group III (n = 6), streptozotocin-induced diabetic; and Group IV (n = 7), GSE-supplemented diabetic rats. Serum paraoxonase activities were determined with a spectrophotometric method. Paraoxonase activities in Group III were significantly lower than in the other three groups (P < .001, P < .001, and P = .005 for Groups I, II, and IV, respectively), and Group IV showed increased paraoxonase activities compared to Group III (P = .005). This is the first study to show an association between paraoxonase status and GSE supplementation and demonstrated that GSE increased paraoxonase activities. This beneficial effect of GSE was more obvious in the diabetic group, which was more prone to atherosclerotic events compared to the healthy population. © 2010, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition.
Yazarlar (4)
1
Aysel Kiyici
2
Nilsel Okudan
3
H. Gökbel
4
Muaz Belviranli
Anahtar Kelimeler
diabetes
grape seed extract
paraoxonase
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
31
Atıf
4
Yazar
3
Anahtar Kelime