Scopus
YÖKSİS Eşleşti
Oxidative stress and anti-oxidant status in diabetic rat liver: Effect of plant polyphenols
Archives of Physiology and Biochemistry · Aralık 2012
YÖKSİS Kayıtları
Oxidative stress and anti oxidant status in diabetic rat liver Effectof plant polyphenols
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY · 2012 SSCI 6 atıf
PROFESÖR NİLSEL OKUDAN →
Oxidative stress and anti oxidant status in diabetic rat liver Effect of plant polyphenols
Archives of Physiology and Biochemistry · 2012 SCI-Expanded
PROFESÖR MUAZ BELVİRANLI →
Makale Bilgileri
DergiArchives of Physiology and Biochemistry
Yayın TarihiAralık 2012
Cilt / Sayfa118 · 237-243
Scopus ID2-s2.0-84869460249
Özet
Increased evidence in role of oxidative stress and grape seed extract (GSE) in diabetes and its complication led us to investigate the changes of oxidative stress and anti-oxidant defence in liver tissue of diabetic rats and possible effects of GSE. Diabetes was induced by a single intraperitoneal injection of streptozotocin. Seven days after STZ injection four groups were formed: Control, GSE-supplemented control, diabetic and GSE-supplemented diabetic and GSE was given for 6 weeks. Malondialdehyde levels and xanthine oxidase activities were not different among the groups. However, nitric oxide (NO) levels were higher in diabetic and GSE supplemented groups compared with non-diabetic and non-supplemented groups, respectively. Total anti-oxidant activity (TAA) was lower in diabetic groups compared with their non-diabetic controls and it was not affected by GSE. In conclusion, GSE supplementation has limited protective effect in liver tissue of diabetic rats via affecting NO levels and was not affecting TAA. © 2012 Informa UK, Ltd.
Yazarlar (4)
1
Muaz Belviranli
2
H. Gökbel
3
Nilsel Okudan
4
Sadik Büyükbaş
Anahtar Kelimeler
Diabetes mellitus
Grape seed extract
Lipid peroxidation
Nitric oxide
Total anti-oxidant activity
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
13
Atıf
4
Yazar
5
Anahtar Kelime