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Scopus 🔓 Açık Erişim YÖKSİS DOI Eşleşti SJR Q3

The role of nitric oxide on the responses of curcumin-treated rat aorta

Bratislava Medical Journal · Aralık 2012

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YÖKSİS Kayıtları
The role of nitric oxide on the responses of curcumin treated rat aorta
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY · 2012 SSCI
Prof. Dr. NİLSEL OKUDAN →
The role of nitric oxide on the responses of curcumin treated rat aorta
Bratislava Medical Journal · 2012 SCI-Expanded
Prof. Dr. MUAZ BELVİRANLI →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

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Makale Bilgileri

ISSN00069248
Yayın TarihiAralık 2012
Cilt / Sayfa113 · 270-273
Erişim🔓 Açık Erişim
Özet Objectives: The aim of the present study was to evaluate the influence of endothelial nitric oxide (NO) on the vascular responses of curcumin-treated rats. Methods: The experimental groups included the control and curcumin-treated (200 mg/kg/day, p.o., for 4 weeks) group. The concentration response curves to receptor-dependent agent 5-hydroxytryptamine(5-HT; 10-9-3×10-4 M) and receptor-independent agent potassium chloride (KCl; 5-100 mM) were observed. Results: The concentration response curves to 5-HT and KCl shifted to the right and the maximal response was significantly decreased in the curcumin-treated rat aortas. A pretreatment of rings with L-NAME (a NOS inhibitor, 10-4 M) increased both the sensitivity and maximal response to only 5-HT. No apparent histological changes were demonstrated in smooth muscle and connective tissue layers in the aortas of the control and curcumin-treated rat preparations. Conclusion: The results of the present study suggest that NO release from endothelial cells modulates curcumin- treated rat aorta responses to 5-HT, but not to KCl.

Yazarlar (6)

1
Kismet Esra Nurullahoglu-Atalik
2
H. Gökbel
3
Mehmet Öz
4
Nilsel Okudan
5
Muaz Belviranli
6
Hasan Esen

Anahtar Kelimeler

Aorta Contractions Curcumine KCl Nitric oxide Serotonin

Kurumlar

Necmettin Erbakan Üniversitesi
Meram Turkey
Selcuklu Faculty of Medicine
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Bratislava Medical Journal
Q3
SJR Skoru0,458
H-Index42
YayıncıSpringer International Publishing
ÜlkeSlovakia
Medicine (miscellaneous) (Q3)
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Metrikler

2
Atıf
6
Yazar
6
Anahtar Kelime

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