Scopus
YÖKSİS Eşleşti
Single and repeated sevoflurane or desflurane exposure does not impair spatial memory performance of young adult mice
Fundamental and Clinical Pharmacology · Aralık 2013
YÖKSİS Kayıtları
Single and repeated sevoflurane or desflurane exposure does not impair spatial memory performance of young adult mice
Fundamental & Clinical Pharmacology · 2013 SCI-Expanded
PROFESÖR MUAZ BELVİRANLI →
Single and repeated sevoflurane or desflurane exposure does not impairspatial memory performance of young adult mice
FUNDAMENTAL & CLINICAL PHARMACOLOGY · 2013 SSCI
PROFESÖR NİLSEL OKUDAN →
Makale Bilgileri
DergiFundamental and Clinical Pharmacology
Yayın TarihiAralık 2013
Cilt / Sayfa27 · 641-649
Scopus ID2-s2.0-84886585970
Özet
Volatile anesthetics are known to disturb the spatial memory in aged rodents, but there is insufficient information on their effects on young adult rodents. The aim of this study was to compare the effects of single and repeated exposure to desflurane and sevoflurane on spatial learning and memory functions in young adult mice. Balb/c mice (2 months old) were randomly divided into six equal groups (n = 8). The groups with single inhalation were exposed to 3.3% sevoflurane or 7.8% desflurane or vehicle gas for 4 h, respectively. The groups with repeated inhalation were exposed to 3.3% sevoflurane or 7.8% desflurane or vehicle gas for 2 h a day during 5 consecutive days. Spatial learning and memory were tested in the Morris water maze 24 h after exposure. In the learning phase, the parameters associated with finding the hidden platform and swimming speed, and in the memory phase, time spent in the target quadrant and the adjacent quadrants, were assessed and compared between the groups. In the 4-day learning process, there was no significant difference between the groups in terms of mean latency to platform, mean distance traveled and average speed (P > 0.05). During the memory-test phase, all mice exhibited spatial memory, but there was no significant difference between the groups in terms of time spent in the target quadrant (P > 0.05). Sevoflurane and desflurane anesthesia did not impair acquisition learning and retention memory in young adult mice. © 2013 Société Française de Pharmacologie et de Thérapeutique.
Yazarlar (4)
1
Alper Kiliçaslan
2
Muaz Belviranli
3
Nilsel Okudan
4
Esra Nurullahoglu Atalik
Anahtar Kelimeler
Desflurane
Memory
Postoperative cognitive dysfunction
Sevoflurane
Volatile anaesthetics
Water maze
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
20
Atıf
4
Yazar
6
Anahtar Kelime